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Fig. 1 | Reproductive Biology and Endocrinology

Fig. 1

From: Chronic effects of an anti-angiogenic thrombospondin-1 mimetic peptide, ABT-898, on female mouse reproductive outcomes

Fig. 1

ABT-898 does not affect the estrous cycle in female mice. Representative vaginal cytology of the estrous cycle in mice dosed with ABT-898 (ae) or 5 % dextrose (fj). Keratinized epithelial cells (a, f) indicative of estrous were used to denote the start of a new estrous cycle. The number of estrous cycles did not significantly differ between ABT-898 and 5 % dextrose groups (3.6 vs 3.3, p = 0.561) over the course of the 21 day dosing period (k). Female reproductive tracts from mice dosed with ABT-898 (l) or 5 % dextrose (m). Gross observations indicated that female reproductive tracts from ABT-898 (l) treated mice did not differ from 5 % dextrose control in size (m), morphology or vascularity. Images (aj) are magnified 400× and scale bars represent 75 μm

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