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Table 1 Anthropometric and clinical characteristics of nIHH patients and their partners for IVF with ICSI

From: Mutations in gonadotropin-releasing hormone signaling pathway in two nIHH patients with successful pregnancy outcomes

Characteristics

Patient 1

Patient 2

Age at first visit to fertility clinic

28 years

31 years

Pubarche (spontaneous)

at 14 years

at 15 years

Heights

170 cm

156 cm

Weight

65 kg

53 kg

Breast development by Tanner scale

Stage V

Stage IV

Sense of odors

Normal

Normal

Karyotype

46, XX

46, XX

MRI of the pituitary

Size: 10 mm x 6 mm x16 mm. Signs of signal reduction in the right half of the posterior pituitary (4 mm x 3 mm x 2 mm), depicting a cyst.

Size: 3.5 mm x 5 mm x 9 mm showing signs of moderate pituitary hypoplasia

Vaginal ultrasound

Uterus: 27 mm x 43 mm x 30 mm

Endometrium: 2.3 mm

Right ovary: 18 mm x 16 mm with 4 follicles (6 to 8 mm).

Left ovary: 17 mm x 18 mm with 5 follicles (6 to 7 mm).

Moderate hypoplasia of the uterus and ovaries.

Uterus: 35 mm x 22 mm x30 mm

Endometrium: 1.8 mm

Right ovary: 21 mm x 18 mm with 3 follicles (3 to 5 mm)

Left ovary: 17 mm x 18 mm with 5 follicles (6 to 7 mm). Moderate hypoplasia of the ovaries.

Partner characteristics for IVF with ICSI

Ejaculate volume: 2 ml

Sperm concentration: 39x106/ml,

Motile sperms: 3 %

Normal forms by Kruger strict criteria: 2 %.

Ejaculate volume: 5 ml

Sperm concentration: 31x106/ml

Motile sperms: None

Normal forms by Kruger strict criteria: 1 %.