Fig. 3
From: Genetic, hormonal and metabolic aspects of PCOS: an update
In a normal cycle, only the dominant follicle responds to LH when it reaches 10Â mm diameter. In PCOS the response to LH occurs inappropriately in smaller follicles and many antral follicles reach terminal differentiation before time, producing a greater quantity of steroids and inhibin B that exert negative feedback on FSH production