Fig. 4
Classification of differentially expressed genes into E2 target genes by Ingenuity Pathway Analysis (IPA). IPA of the differentially regulated genes post AI treatment shows a network of 26 focus molecules. The network is displayed graphically as nodes (gene/gene products) and edges (biological relationship between nodes). They are represented by different shapes with their expected regulation of a particular cellular or biological function. The red and green nodes represent up and down regulated genes or their products. The intensity of node colour indicates the abundance and various shapes of the nodes represent molecular class of the gene product. The solid lines indicate interaction of molecules being discussed that have been validated through various experiments and reported in literature. On the other hand, the dashed lines are tentative interaction which are not yet completely validated and are based on computationally designed programs