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Table 3 Probabilities of APOB concentration in human FF, divided into quartiles (Q), to predict IVF/ICSI outcomes

From: Apolipoprotein B is regulated by gonadotropins and constitutes a predictive biomarker of IVF outcomes

APOB quartiles (ng/ml) n / number of FF analyzed (%) P Crude OR [95 % CI] p-value Adjusted OR [95 % CI]a p-value
Probabilities of obtaining an oocyte
 Q1 (<112) 24/50 (48.0) 0.001 -- (reference)   -- (reference)  
 Q2 (≥112, <230) 40/51 (78.4) 3.9 [1.65–9.4] 0.002 3.4 [1.04–11.2] 0.044
 Q3 (≥230, <330) 39/49 (79.6) 4.2 [1.73–10,3] 0.002 3.3 [1.19–9.08] 0.022
 Q4 (≥330) 40/51 (78.4) 3.9 [1.65–9.4] 0.002 3.4 [1.01–11.44] 0.049
Probabilities of obtaining a fertilized oocyte
 Q1(<112) 12/50 (24.0) <0.001 -- (reference)   -- (reference)  
 Q2 (≥112, <230) 34/51 (66.7) 6.2 [1.79–21.76] 0.004 7.3 [1.59;33.43] 0.011
 Q3 (≥230, <330) 33/49 (67.3) 10.1 [2.38–42.69] 0.002 11.2 [1.67;75.63] 0.013
 Q4 (≥330) 28/51 (55.0) 6.4 [1.69–24.37] 0.006 6.3 [1.13;34.86] 0.035
Probabilities of obtaining an embryo on day 2
 Q1(<112) 5/50 (10.0) <0.001 -- (reference)   -- (reference)  
 Q2 (≥112, <230) 32/51 (62.8) 15.2 [5.11–44.95] <0.001 17.3 [2.2;137.1] 0.007
 Q3 (≥230, <330) 31/49 (63.3) 15.5 [5.19–46.29] <0.001 15.5 [1.9;130.3] 0.011
 Q4 (≥330) 24/51 (47.1) 8 [2.72–23.51] <0.001 8.3 [0.8;82.0] 0.071
Probabilities of obtaining a top quality embryo on day 2
 Q1(<112) 4/50 (8.0) 0.047 -- (reference)   -- (reference)  
 Q2 (≥112, <230) 14/51 (27.5) 4.4 [1.32–14.38] 0.016 4.8 [1.04;22.41] 0.045
 Q3 (≥230, <330) 13/49 (26.5) 4.2 [1.24–13.86] 0.021 4.1 [0.75;22.64] NS
 Q4 (≥330) 14/51 (27.4) 4.4 [1.32–14.38] 0.016 3.9 [0.64;23.91] NS
  1. aProbabilities to obtain an oocyte and an embryo were adjusted for age and aetiology of infertility. Probabilities to obtain a fertilized oocyte and a top embryo were adjusted for age. Q1, quartile 1; Q2, quartile 2; Q3, quartile 3; Q4, quartile 4. Q1 was considered as the reference. OR Odds Ratio, CI confidence intervals, FF Follicular Fluid, NS No significant