Flutamide induces alterations in the cell-cell junction ultrastructure and reduces the expression of Cx43 at the blood-testis barrier with no disturbance in the rat seminiferous tubule morphology

Table 1 Diameter of the seminiferous tubules, the area occupied by Leydig cells and the number of Leydig cells per unit area of interstitial tissue in control and flutamide-exposed rats

	Control	Flutamide-treated
Diameter of the seminiferous tubules (μm)	287.80 ± 32.09	295.11 ± 35.98
The area occupied by Leydig cells per 40 fields of vision (mm²)	3.42 ± 0.11	5.18 ± 0.28*
The number of Leydig cells per 1 mm² of interstitial tissue	5984.87 ± 905.91	3275.30 ± 390.41**

Data are expressed as means ± SD. Significant differences from control values are denoted as ^* p < 0.05 and ^** p < 0.05 (n = 6 animals/each group)

ISSN: 1477-7827