Association of TNF-α genetic polymorphisms with recurrent pregnancy loss risk: a systematic review and meta-analysis

Li, Hui-Hui; Xu, Xing-Hua; Tong, Jing; Zhang, Kai-Yue; Zhang, Cong; Chen, Zi-Jiang

doi:10.1186/s12958-016-0140-6

Table 1 Main characteristics of the studies included in the meta-analysis

From: Association of TNF-α genetic polymorphisms with recurrent pregnancy loss risk: a systematic review and meta-analysis

Gene polymorphism	Author	Year	Country	Diagnostic Criteria(numbers of consecutive pregnancy losses)	Genotype		Genotype method	Quality Assessment
Gene polymorphism	Author	Year	Country		Case	Control	Genotype method	Quality Assessment
-238G/A	Alkhuriji A.F	2013	Saudi	three or more	57/8/0^a	55/7/3^a	PCR	1: adequate; 2: not stated;3: adequate;
-238G/A	Alkhuriji A.F	2013	Saudi	three or more	57/8/0^a	55/7/3^a	PCR	4: adequate; 5: unequal
	Gupta R.	2012	Indian	three or more	121/63/16^a	154/113/33^a	PCR–RFLP	1: adequate; 2: not stated;3: adequate;
	Gupta R.	2012	Indian	three or more	121/63/16^a	154/113/33^a	PCR–RFLP	4: adequate; 5: not stated
	Finana R.R.	2010	Bahrain	three or more	148/52/4^a	200/48/0^a	PCR–RFLP	1: adequate; 2: not stated;3: adequate;
	Finana R.R.	2010	Bahrain	three or more	148/52/4^a	200/48/0^a	PCR–RFLP	4: adequate; 5: unequal
	Zammiti W	2009	Tunisia	three or more	264/88/20^a	215/52/7^a	PCR–RFLP	1: adequate; 2: not stated;3: adequate;
	Zammiti W	2009	Tunisia	three or more	264/88/20^a	215/52/7^a	PCR–RFLP	4: adequate; 5: unequal
-308G/A	Alkhuriji A.F	2013	Saudi	three or more	33/24/8^a	47/14/4^a	PCR	1: adequate; 2: not stated;3: adequate;
-308G/A	Alkhuriji A.F	2013	Saudi	three or more	33/24/8^a	47/14/4^a	PCR	4: adequate; 5: unequal
	Gupta R.	2012	Indian	three or more	229/62/9^a	425/70/5^a	PCR–RFLP	1: adequate; 2: not stated;3: adequate;
	Gupta R.	2012	Indian	three or more	229/62/9^a	425/70/5^a	PCR–RFLP	4: adequate; 5: unequal
	Kuar A.	2011	Indian	three or more	39/6/5^a	41/7/2^a	PCR–RFLP	1: adequate; 2: not stated;3: adequate;
	Kuar A.	2011	Indian	three or more	39/6/5^a	41/7/2^a	PCR–RFLP	4: adequate; 5: unequal
	Finana R.R.	2010	Bahrain	three or more	164/32/8^a	212/32/4^a	PCR–RFLP	1: adequate; 2: not stated;3: adequate;
	Finana R.R.	2010	Bahrain	three or more	164/32/8^a	212/32/4^a	PCR–RFLP	4: adequate; 5: not stated
	Zammiti W	2009	Tunisia	three or more	319/39/14^a	222/47/5^a	PCR–RFLP	1: adequate; 2: not stated;3: adequate;
	Zammiti W	2009	Tunisia	three or more	319/39/14^a	222/47/5^a	PCR–RFLP	4: adequate; 5: not stated
	Kamali- Sarvestani E	2005	Iranian	three or more	117/14^b	122/21^b	PCR	1: adequate; 2: not stated;3: adequate;
	Kamali- Sarvestani E	2005	Iranian	three or more	117/14^b	122/21^b	PCR	4: adequate; 5: not stated
	Prigoshin N	2004	Argentina	three or more	35/6^b	49/5^b	PCR-SSP	1: adequate; 2: not stated;3: adequate;
	Prigoshin N	2004	Argentina	three or more	35/6^b	49/5^b	PCR-SSP	4: adequate; 5: unequal
	Pietrowski D	2004	Germany	three or more	133/33/2^a	167/41/4^a	PCR	1: adequate; 2: not stated;3: adequate;
	Pietrowski D	2004	Germany	three or more	133/33/2^a	167/41/4^a	PCR	4: adequate; 5: not stated
	Daher S	2003	Brazil	three or more	36/12^b	89/19^b	PCR	1: adequate; 2: not stated;3: adequate;
	Daher S	2003	Brazil	three or more	36/12^b	89/19^b	PCR	4: adequate; 5: unequal
	Babbage S.J.	2001	UK	three or more	30/13^b	56/17^b	PCR	1: adequate; 2: not stated;3: adequate;
	Babbage S.J.	2001	UK	three or more	30/13^b	56/17^b	PCR	4: adequate; 5: unequal

Note: ^aGenotype, for TNF-308G/A, GG/GA/AA; for TNF-238G/A, GG/GA/AA. ^bGenotype, for TNF-308G/A, GG/GA+AA; for TNF-238G/A, GG/GA+AA
PCR, polymerase chain reaction; RFLP, restriction fragment length polymorphism

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