Dehydroepiandrosterone plus climen supplementation shows better effects than dehydroepiandrosterone alone on infertility patients with diminished ovarian reserve of low-FSH level undergoing in-vitro fertilization cycles: a randomized controlled trial

Table 2 Comparison of the ovarian reserve markers pre- and post-treatment in each group

	The DHEA group		P-value	The DHEA plus climen group		P-value
	Pre-treament	Post-treatment	P-value	Pre-treament	Post-treatment	P-value
AMH (ng/ml)	0.98 ± 0.72	1.24 ± 1.07	0.015	0.90 ± 0.66	1.14 ± 0.79	0.001
FSH(IU/L)	12.93 ± 7.02	10.03 ± 5.48	0.003	11.86 ± 5.29	9.08 ± 5.51	0.001
E2 (pmol/L)	181.53 ± 137.26	113.96 ± 70.00	0.001	160.65 ± 116.90	278.50 ± 135.80	0.000
High-FSH subgroups
AMH (ng/ml)	0.88 ± 0.65	0.99 ± 1.06	0.322	0.68 ± 0.58	0.89 ± 0.75	0.034
FSH (IU/L)	17.35 ± 6.34	11.84 ± 6.45	0.001	15.40 ± 4.00	10.56 ± 6.54	0.001
E2 (pmol/L)	155.70 ± 93.43	122.32 ± 79.44	0.070	120.35 ± 81.91	276.30 ± 139.76	0.000
Low-FSH subgroups
AMH (ng/ml)	1.11 ± 0.78	1.56 ± 1.01	0.002	1.18 ± 0.67	1.45 ± 0.74	0.004
FSH (IU/L)	7.24 ± 1.82	7.69 ± 2.49	0.445	7.13 ± 2.11	7.14 ± 2.87	0.982
E2 (pmol/L)	214.75 ± 174.96	103.21 ± 55.14	0.003	213.37 ± 135.26	281.53 ± 133.33	0.035

Data are presented as mean ± SD (standard deviation) or percentage as appropriate. Subgroups were divided based on a basal FSH level cut-off of 10 mlU/ml
P <0.05 was considered as statistically significant

ISSN: 1477-7827