Fig. 1

Schematic model of AMH actions in the ovary. Dewailly, D., et al., Hum Reprod Update, 2014 [24]. AMH, produced by the granulosa cells of small growing follicles, inhibits initial follicle recruitment and FSH-dependent growth and selection of pre antral and small antral follicles. In addition, AMH remains highly expressed in cumulus cells of mature follicles. The inset shows in more detail the inhibitory effect of AMH on FSH-induced CYP19a1 expression leading to reduced estradiol (E2) levels, and the inhibitory effect of E2 itself on AMH expression. T, testosterone; Cyp19a1, aromatase. Figure modified from van Houten et al. (2010)