Fig. 1From: Decidualisation of human endometrial stromal cells is associated with increased expression and secretion of proreninProrenin/prorenin receptor activated pathways. Prorenin bound to the prorenin receptor ((P)RR) unfolds and can catalyse the formation of Ang I from AGT promoting the formation of downstream Ang peptides such as Ang II. Prorenin bound to the (P)RR activates ERK1/2 signalling, p38/HSP27 signalling, and causes translocation of PLZF to the nucleus which activates p85α-PI3K and down regulates (P)RR expression. The (P)RR can also activate the Wnt/β-catenin cascadeBack to article page