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Table 2 Details of the Human Participants Included in the Study

From: Very small embryonic-like stem cells (VSELs) detected in azoospermic testicular biopsies of adult survivors of childhood cancer

No

Current Age of Cancer Survivor

Age at Diagnosis

of Cancer

Type of Cancer;

Treatment Regimen given to Treat Cancer (with alkylating agent doses)

Semen Analysis

FSH

Testo-sterone

1

35 years

12 years

Hodgkin’s Lymphoma; CT + RT

CT : Cyclophosphamide-9.6gm/m2

RT to bilateral neck 40Gy/20#

Azoospermia

-

-

2

35 years

12.6 years

Lymphoblastic lymphoma;CT+ RT

CT : Cyclophosphamide 22.4gm/m2

RT : Cranial 18Gy/9#

Mediastinum 40 Gy/20#

Azoospermia

-

-

3

30 year

5 years at first diagnosis

27 years at recurrence

Non Hodgkin’s lymphoma with recurrence/ transformation to Diffuse Large B cell Lymphoma

Surgery + CT+ RT

Surgery-Right Orchiectomy

CT: Cyclophosphamide 16gm/m2

RT: Cranial 18Gy/9#

CT alone

Cyclophosphamide-5.5 gm/m2

Azoospermia

WNL

WNL

4

35 years

8 years

Wilms tumor : Surgery + CT+ RT

Surgery-Left nephrectomy

CT: Cyclophosphamide-10.8 gm/m2,

RT to left renal fossa 20 Gy/7#

Azoospermia

Elevated

WNL

5

28 years

7 years

Hodgkin Lymphoma; CT + RT

CT : Cyclophosphamide- 9.3 gm/m2; Procarbazine-10 gm/m2

RT to bilateral neck 36 Gy/18#

Azoospermia

Elevated

WNL

6

23 years

13 years

Non Hodgkin lymphoma;CT + RT

CT :Cyclophosphamide 20 g/m2

RT: Cranial 19.8Gy/11#

Azoospermia

Elevated

Elevated

7

25 years

10 year

Non Hodgkin lymphoma; CT + RT

CT : Cyclophosphamide 19gm/m2

RT: Cranial 19.8Gy/11#

Azoospermia

Elevated

Elevated

  1. CT – chemotherapy; RT- Radiotherapy; Gy –gray; WNL- Within normal range