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Table 1 The effect of ADM treatment on the up-regulated cytokines in tubal ectopic pregnancy (tEP) oviducts (N = 5)

From: Effects of adrenomedullin on the expression of inflammatory cytokines and chemokines in oviducts from women with tubal ectopic pregnancy: an in-vitro experimental study

Symbol Protein name tEP vs control tEP + ADM vs tEP
Fold change P value^ Fold change P value#
Pro-inflammatory cytokines
    GM-CSF Granulocyte-macrophage colony-stimulating factor 2.5173 0.032* 0.3204 0.032*
    IL-7 Interleukin 7 2.5057 0.032* 0.2167 0.043*
    IFN-gamma Interferon-gamma 2.1281 0.032* 0.5332 0.080
    TNF-beta Tumour necrosis factor-beta 1.8817 0.016* 0.4897 0.043*
Anti-inflammatory cytokines
    IL-10 Interleukin 10 1.8760 0.008* 0.6194 0.043*
    HGF Hepatocyte growth factor 1.5196 0.032* 0.7346 0.043*
Pro- and anti-inflammatory cytokines
    IL-4 Interleukin 4 2.3493 0.032* 0.3941 0.043*
    IL-6 Interleukin 6 4.1152 0.016* 0.1135 0.043*
  1. Cytokines which were significantly up-regulated (p < 0.05) in tEP oviducts (N = 5) compared to controls (N = 5) are listed. To study the effect of ADM on the expression of these up-regulated cytokines, tEP oviducts were treated with 100 nM ADM for 24 h. (*statistically significant, P < 0.05; ^Mann–Whitney U test; #Wilcoxon signed rank test)