Effects of adrenomedullin on the expression of inflammatory cytokines and chemokines in oviducts from women with tubal ectopic pregnancy: an in-vitro experimental study

Table 1 The effect of ADM treatment on the up-regulated cytokines in tubal ectopic pregnancy (tEP) oviducts (N = 5)

Symbol	Protein name	tEP vs control		tEP + ADM vs tEP
Symbol	Protein name	Fold change	P value^	Fold change	P value#
Pro-inflammatory cytokines
GM-CSF	Granulocyte-macrophage colony-stimulating factor	2.5173	0.032*	0.3204	0.032*
IL-7	Interleukin 7	2.5057	0.032*	0.2167	0.043*
IFN-gamma	Interferon-gamma	2.1281	0.032*	0.5332	0.080
TNF-beta	Tumour necrosis factor-beta	1.8817	0.016*	0.4897	0.043*
Anti-inflammatory cytokines
IL-10	Interleukin 10	1.8760	0.008*	0.6194	0.043*
HGF	Hepatocyte growth factor	1.5196	0.032*	0.7346	0.043*
Pro- and anti-inflammatory cytokines
IL-4	Interleukin 4	2.3493	0.032*	0.3941	0.043*
IL-6	Interleukin 6	4.1152	0.016*	0.1135	0.043*

Cytokines which were significantly up-regulated (p < 0.05) in tEP oviducts (N = 5) compared to controls (N = 5) are listed. To study the effect of ADM on the expression of these up-regulated cytokines, tEP oviducts were treated with 100 nM ADM for 24 h. (*statistically significant, P < 0.05; ^Mann–Whitney U test; #Wilcoxon signed rank test)

ISSN: 1477-7827