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Table 2 Serum E2 levels and ovarian stimulation and fertilization outcomes

From: The association of serum estradiol level with outcomes of clomiphene citrate/human menopausal gonadotropin ovarian stimulation for in vitro fertilization and embryo transfer

  Group A: Group B: Group C: P P adj e
E2 ≤30 pg/ml 30< E2 ≤50 pg/ml E2 >50 pg/ml
Number of cycles 316 451 313   
FSH during ovulation stimulation, IU/La 9.5 (7.5, 11.8) 8.9 (7.5, 10.6) 9 (7.7, 11) 0.098 0.047
Duration of stimulation, daysa 9 (8, 10) 8 (7, 10)* 8 (7, 9)* ** <0.001 <0.001
Gonadotropin, ampules 16 (12.5, 18) 14 (10, 18)* 14 (10.8, 17.5)* <0.001 <0.001
E2 at HCG day, pg/mla 2216 (1391, 3319) 2150.5 (1406, 3294) 2179.5 (1337.5, 3223) 0.991 0.976
Number of eggsa 6 (3, 9) 5 (3, 8) 5 (2, 7)* 0.004 0.031
Number of mature oocytes (MII)a 5 (3, 8) 4 (2, 7) 4 (2, 6)* 0.003 0.032
Number of embryosa 2 (1, 4) 2 (1, 4) 2 (1, 4) 0.340 0.771
Number of good quality embryosa 2 (1, 4) 2 (1, 3) 2 (1, 3) 0.440 0.638
Successful fertilizationb,c 1470 (82.7) 1968 (84.2) 1261 (82.9) 0.375 0.756
Successful cleavageb,d 1432 (97.4) 1917 (97.4) 1217 (96.5) 0.257 0.995
Cancelled cyclesb 46 (14.6) 55 (12.2) 52 (16.6) 0.221 0.290 (Group B), 0.766 (Group C)
  1. E 2 estradiol, HCG human chorionic gonadotropin
  2. Continuous data are presented as median (interquartile range), and examined by Kruskal-Wallisa test. Categorical data are expressed as n (%) and tested by Chi-squareb test
  3. cFertilization rate was calculated as: total number of fertilized oocytes/total number of mature oocytes
  4. dCleavage rate was calculated as: total number of cleaved oocytes/total number of fertilized oocytes
  5. eRank transformation was applied to continuous data, and tested by analysis of covariance adjusting for age, body mass index (BMI), and baseline E2 level. Successful fertilization and cleavage rate were tested by Poisson regression adjusting for age, BMI, and baseline E2 level. Probability of cancelled cycle was examined by logistic regression adjusting for age, BMI, and baseline E2 level
  6. *Indicates significant difference between group A and given group, P < 0.017
  7. *Indicates significant difference between group B and group C, P < 0.017