Skip to main content

Table 2 Serum E2 levels and ovarian stimulation and fertilization outcomes

From: The association of serum estradiol level with outcomes of clomiphene citrate/human menopausal gonadotropin ovarian stimulation for in vitro fertilization and embryo transfer

 

Group A:

Group B:

Group C:

P

P adj e

E2 ≤30 pg/ml

30< E2 ≤50 pg/ml

E2 >50 pg/ml

Number of cycles

316

451

313

  

FSH during ovulation stimulation, IU/La

9.5 (7.5, 11.8)

8.9 (7.5, 10.6)

9 (7.7, 11)

0.098

0.047

Duration of stimulation, daysa

9 (8, 10)

8 (7, 10)*

8 (7, 9)* **

<0.001

<0.001

Gonadotropin, ampules

16 (12.5, 18)

14 (10, 18)*

14 (10.8, 17.5)*

<0.001

<0.001

E2 at HCG day, pg/mla

2216 (1391, 3319)

2150.5 (1406, 3294)

2179.5 (1337.5, 3223)

0.991

0.976

Number of eggsa

6 (3, 9)

5 (3, 8)

5 (2, 7)*

0.004

0.031

Number of mature oocytes (MII)a

5 (3, 8)

4 (2, 7)

4 (2, 6)*

0.003

0.032

Number of embryosa

2 (1, 4)

2 (1, 4)

2 (1, 4)

0.340

0.771

Number of good quality embryosa

2 (1, 4)

2 (1, 3)

2 (1, 3)

0.440

0.638

Successful fertilizationb,c

1470 (82.7)

1968 (84.2)

1261 (82.9)

0.375

0.756

Successful cleavageb,d

1432 (97.4)

1917 (97.4)

1217 (96.5)

0.257

0.995

Cancelled cyclesb

46 (14.6)

55 (12.2)

52 (16.6)

0.221

0.290 (Group B), 0.766 (Group C)

  1. E 2 estradiol, HCG human chorionic gonadotropin
  2. Continuous data are presented as median (interquartile range), and examined by Kruskal-Wallisa test. Categorical data are expressed as n (%) and tested by Chi-squareb test
  3. cFertilization rate was calculated as: total number of fertilized oocytes/total number of mature oocytes
  4. dCleavage rate was calculated as: total number of cleaved oocytes/total number of fertilized oocytes
  5. eRank transformation was applied to continuous data, and tested by analysis of covariance adjusting for age, body mass index (BMI), and baseline E2 level. Successful fertilization and cleavage rate were tested by Poisson regression adjusting for age, BMI, and baseline E2 level. Probability of cancelled cycle was examined by logistic regression adjusting for age, BMI, and baseline E2 level
  6. *Indicates significant difference between group A and given group, P < 0.017
  7. *Indicates significant difference between group B and group C, P < 0.017