Fig. 1

KP54 administration to female WT mice on D4 of pregnancy triggers p38 and ERK1/2 phosphorylation but not SAPK/JNK. Phosphorylated p38 expression in the D4 pregnant uterus following PBS-treatment (a); part of the uterus shown in (a) is magnified to better reveal details on the endometrial glands (b). Posphorylated p38 (p-p38) expression in the D4 pregnant uterus following KP54-treatment (c); parts of the uterus shown in (c) are magnified to better reveal details on the endometrial glands and luminal epithelium (d and e). Phosphorylated p38 expression in the non-pregnant uterus following PBS- (f) or KP54 (g) treatment. Phosphorylated ERK1/2 (pERK1/2) expression in the D4 pregnant uterus following PBS-treatment (h) or KP54-treatment (i); part of the uterus shown in (i) is magnified to better reveal details on the luminal epithelium (j). Phosphorylated SAPK/JNK (pSAPK/pJNK) expression in the D4 pregnant uterus following PBS-treatment (k) or KP54-treatment (l). AM: anti-mesometrial pole; LM: longitudinal muscle of the myometrium; CM: circular muscle of the myometrium; E: endometrium; LE: luminal epithelium; GE: glandular epithelium; M: mesometrial pole; UL: uterine lumen