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Fig. 2 | Reproductive Biology and Endocrinology

Fig. 2

From: Dopamine agonist inhibits vascular endothelial growth factor protein production and secretion in granulosa cells

Fig. 2

Post-transcriptional regulation of VEGF by the dopamine receptor 2 agonist, Cabergoline. Intracellular and extracellular quantification of VEGF by ELISA in LGCs (n = 6) cultured for 8 h in hCG with or without Cb2 in the (a) absence or (b) presence of BFA. c Intracellular, extracellular, and total VEGF levels expressed as pg/mL (mean ± SD). In the absence of BFA (−) extracellular VEGF in Cb2-untreated LGCs were higher than intracellular VEGF levels. However, in the presence of BFA (+) the intracellular VEGF in Cb2-treated LGCs is lower than in Cb2-untreated cells. ǂ p < 0.05 compared to VEGF levels in Cb2-treated LGCs vs Cb2-untreated LGCs; *p < 0.05 compared to intracellular vs extracellular VEGF levels in absence of BFA

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