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Fig. 1 | Reproductive Biology and Endocrinology

Fig. 1

From: Dopamine agonist inhibits vascular endothelial growth factor protein production and secretion in granulosa cells

Fig. 1

VEGF mRNA is not altered by the dopamine receptor 2 agonist Cabergoline. Time-course experiments designed to study the effects of the dopamine receptor 2 agonist (D2-ag) Cabergoline (Cb2) on VEGF mRNA stability (expressed as the percentage of VEGF mRNA degradation) in LGCs. LGCs (n = 6) were pre-incubated with actinomycin D (ActD), then treated with Cb2, hCG, and ActD for 1, 2, or 4 h or untreated. The amount of VEGF cDNA at time point 0 was assigned a value of 100 and the percentage of degraded mRNA was estimated according to variations in the Ct determined by QF-RT-PCR. No significant differences in VEGF mRNA stability were observed in LGCs treated with Cb2 compared to untreated LGCs

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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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