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Table 5 Steroid hormone metabolite[μg/mmol urinary creatinine]

From: Gestation-specific reference intervals for comprehensive spot urinary steroid hormone metabolite analysis in normal singleton pregnancy and 6 weeks postpartum

  1st trimester (n = 81) 2nd trimester (n = 40) 3rd trimester (n = 40)
   Reference intervals    Reference intervals    Reference intervals
move to a separate row Mean ± SD Median 2.5th percentile [90 % CI] 97.5th percentile [90 % CI] Mean ± SD Median 2.5th percentile [90 % CI] 97.5th percentile [90 % CI] Mean ± SD Median 2.5th percentile [90 % CI] 97.5th percentile [90 % CI]
Cortisone 34.6 ± 25.2 28.4 4.7 [4.4, 10.2] 110 [97.7, 113] 64.5 ± 39.8 53.3 14.1 [14.0, 25.8] 165 [161, 165] 79.1 ± 43.0 82.3 4.8 [4.7, 22.6] 180 [144, 181]
Tetrahydrocortisone 368 ± 165 349 77.6 [73.4, 162] 780 [644, 624] 308 ± 190 255 73.8 [73.4, 90.5] 948 [926, 947] 321 ± 210 267 5.9 [4.7, 101] 923 [748, 922]
α-Cortolon 227 ± 170 211 27.6 [17.7, 35.8] 715 [641, 725] 112 ± 138 75.9 15.7 [15.7, 26.0] 826 [583, 825] 148 ± 196 68.7 17.5 [17.5, 22.5] 752 [741, 752]
β-Cortolon 47.9 ± 37.9 43.4 2.5 [1.5, 5.1] 141 [122, 167] 27.5 ± 36.5 13.3 3.8 [3.8, 4.8] 179 [148, 178] 35.0 ± 55.1 11.2 3.6 [3.5, 7.5] 303 [122, 308]
Cortisone 34.6 ± 25.2 28.4 4.7 [4.4, 10.2] 110 [97.7, 113] 64.5 ± 39.8 53.3 14.1 [14.0, 25.8] 165 [161, 165] 79.1 ± 43.0 82.3 4.8 [4.7, 22.6] 180 [144, 181]
20α-Dihydrocortisone 5.4 ± 3.2 4.3 1.5 [1.4, 2.2] 14.9 [12.9, 15.2] 8.2 ± 3.8 7.2 2.4 [2.4, 4.2] 15.0 [14.3, 15.0] 9.8 ± 4.7 9.4 1.4 [1.4, 4.3] 19.1 [18.9, 19.1]
20β-Dihydrocortisone 22.2 ± 11.9 21.2 4.2 [3.7, 8.2] 52.7 [49.9, 54.2] 34.0 ± 16.5 35.3 5.7 [5.6, 12.6] 70.0 [67.4, 70.0] 45.8 ± 26.9 37.7 1.8 [1.7, 14.2] 109 [104, 109]
Cortisol metabolites
 Cortisol 29.1 ± 23.4 20 4.7 [1.5, 7.6] 102 [83.7, 119] 52.3 ± 42.3 38.8 7.9 [7.8, 17.3] 210 [168, 210] 98.2 ± 109 69.6 2.7 [2.5, 24.5] 641 [285, 650]
 Tetrahydrocortisol 191 ± 99.6 178 26.2 [22.2, 73.1] 405 [389, 519] 136 ± 68.1 131 31.4 [31.2, 58.8] 296 [277, 296] 182 ± 202 123 15.7 [15.6, 52.9] 923 [823, 926]
 5α-Tetrahydrocortisol 126 ± 111 90.0 13.2 [9.6, 27.8] 412 [379, 538] 54.7 ± 42.2 54.7 4.6 [4.6, 18.4] 158 [157, 158] 46.7 ± 55.2 29.2 1.3 [1.2, 10.3] 258 [218, 259]
 α-Cortol 55.5 ± 32.0 49.9 8.9 [8.2, 18.5] 145 [111, 192] 37.4 ± 17.9 34.6 7.1 [6.9, 18.6] 107 [73.5, 108] 51.1 ± 56.5 35.1 6.0 [5.9, 12] 248 [235, 248]
 β-Cortol 45.6 ± 22.8 39.9 14.9 [11.8, 21.0] 118 [10.0, 122] 32.4 ± 16.7 26.6 6.9 [6.7, 15.2] 80.0 [68.2, 80.3] 36.3 ± 33.5 24.1 6.3 [6.2, 13.2] 187 [101, 189]
 20α-Dihydrocortisol 30.0 ± 33.7 19.7 1.9 [1.8, 6.6] 180 [117, 215] 60.4 ± 60.2 37.3 1.7 [1.6, 9.5] 258 [246, 258] 145 ± 203 74.8 5.1 [4.9, 18.3] 1049 [623, 1060]