Gestation-specific reference intervals for comprehensive spot urinary steroid hormone metabolite analysis in normal singleton pregnancy and 6 weeks postpartum

Mistry, Hiten D.; Eisele, Nicole; Escher, Geneviève; Dick, Bernhard; Surbek, Daniel; Delles, Christian; Currie, Gemma; Schlembach, Dietmar; Mohaupt, Markus G.; Gennari-Moser, Carine

doi:10.1186/s12958-015-0100-6

Table 5 Steroid hormone metabolite[μg/mmol urinary creatinine]

From: Gestation-specific reference intervals for comprehensive spot urinary steroid hormone metabolite analysis in normal singleton pregnancy and 6 weeks postpartum

	1^st trimester (n = 81)				2^nd trimester (n = 40)				3^rd trimester (n = 40)
			Reference intervals				Reference intervals				Reference intervals
move to a separate row	Mean ± SD	Median	2.5^th percentile [90 % CI]	97.5^th percentile [90 % CI]	Mean ± SD	Median	2.5^th percentile [90 % CI]	97.5^th percentile [90 % CI]	Mean ± SD	Median	2.5^th percentile [90 % CI]	97.5^th percentile [90 % CI]
Cortisone	34.6 ± 25.2	28.4	4.7 [4.4, 10.2]	110 [97.7, 113]	64.5 ± 39.8	53.3	14.1 [14.0, 25.8]	165 [161, 165]	79.1 ± 43.0	82.3	4.8 [4.7, 22.6]	180 [144, 181]
Tetrahydrocortisone	368 ± 165	349	77.6 [73.4, 162]	780 [644, 624]	308 ± 190	255	73.8 [73.4, 90.5]	948 [926, 947]	321 ± 210	267	5.9 [4.7, 101]	923 [748, 922]
α-Cortolon	227 ± 170	211	27.6 [17.7, 35.8]	715 [641, 725]	112 ± 138	75.9	15.7 [15.7, 26.0]	826 [583, 825]	148 ± 196	68.7	17.5 [17.5, 22.5]	752 [741, 752]
β-Cortolon	47.9 ± 37.9	43.4	2.5 [1.5, 5.1]	141 [122, 167]	27.5 ± 36.5	13.3	3.8 [3.8, 4.8]	179 [148, 178]	35.0 ± 55.1	11.2	3.6 [3.5, 7.5]	303 [122, 308]
Cortisone	34.6 ± 25.2	28.4	4.7 [4.4, 10.2]	110 [97.7, 113]	64.5 ± 39.8	53.3	14.1 [14.0, 25.8]	165 [161, 165]	79.1 ± 43.0	82.3	4.8 [4.7, 22.6]	180 [144, 181]
20α-Dihydrocortisone	5.4 ± 3.2	4.3	1.5 [1.4, 2.2]	14.9 [12.9, 15.2]	8.2 ± 3.8	7.2	2.4 [2.4, 4.2]	15.0 [14.3, 15.0]	9.8 ± 4.7	9.4	1.4 [1.4, 4.3]	19.1 [18.9, 19.1]
20β-Dihydrocortisone	22.2 ± 11.9	21.2	4.2 [3.7, 8.2]	52.7 [49.9, 54.2]	34.0 ± 16.5	35.3	5.7 [5.6, 12.6]	70.0 [67.4, 70.0]	45.8 ± 26.9	37.7	1.8 [1.7, 14.2]	109 [104, 109]
Cortisol metabolites
Cortisol	29.1 ± 23.4	20	4.7 [1.5, 7.6]	102 [83.7, 119]	52.3 ± 42.3	38.8	7.9 [7.8, 17.3]	210 [168, 210]	98.2 ± 109	69.6	2.7 [2.5, 24.5]	641 [285, 650]
Tetrahydrocortisol	191 ± 99.6	178	26.2 [22.2, 73.1]	405 [389, 519]	136 ± 68.1	131	31.4 [31.2, 58.8]	296 [277, 296]	182 ± 202	123	15.7 [15.6, 52.9]	923 [823, 926]
5α-Tetrahydrocortisol	126 ± 111	90.0	13.2 [9.6, 27.8]	412 [379, 538]	54.7 ± 42.2	54.7	4.6 [4.6, 18.4]	158 [157, 158]	46.7 ± 55.2	29.2	1.3 [1.2, 10.3]	258 [218, 259]
α-Cortol	55.5 ± 32.0	49.9	8.9 [8.2, 18.5]	145 [111, 192]	37.4 ± 17.9	34.6	7.1 [6.9, 18.6]	107 [73.5, 108]	51.1 ± 56.5	35.1	6.0 [5.9, 12]	248 [235, 248]
β-Cortol	45.6 ± 22.8	39.9	14.9 [11.8, 21.0]	118 [10.0, 122]	32.4 ± 16.7	26.6	6.9 [6.7, 15.2]	80.0 [68.2, 80.3]	36.3 ± 33.5	24.1	6.3 [6.2, 13.2]	187 [101, 189]
20α-Dihydrocortisol	30.0 ± 33.7	19.7	1.9 [1.8, 6.6]	180 [117, 215]	60.4 ± 60.2	37.3	1.7 [1.6, 9.5]	258 [246, 258]	145 ± 203	74.8	5.1 [4.9, 18.3]	1049 [623, 1060]

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