Reproductive Biology and Endocrinology

Table 3 Steroid hormone metabolite[μg/mmol urinary creatinine]

From: Gestation-specific reference intervals for comprehensive spot urinary steroid hormone metabolite analysis in normal singleton pregnancy and 6 weeks postpartum

	1^st trimester (n = 81)				2^nd trimester (n = 40)				3^rd trimester (n = 40)
			Reference intervals				Reference intervals				Reference intervals
move to a separate row	Mean ± SD	Median	2.5^th percentile [90 % CI]	97.5^th percentile [90 % CI]	Mean ± SD	Median	2.5^th percentile [90 % CI]	97.5^th percentile [90 % CI]	Mean ± SD	Median	2.5^th percentile [90 % CI]	97.5^th percentile [90 % CI]
Estriol	135 ± 151	79.9	10.6 [3.5, 17.0]	545 [489, 901]	975 ± 584	836	143 [143, 2881]	2877 [2660, 2881]	2651 ± 2651	1955	636 [636, 764]	15192 [9171, 15116]
17β-Estradiol	9.1 ± 6.7	7.3	0.7 [0.6, 2.1]	26.4 [24.8, 28.8]	16.6 ± 12.0	14.5	1.8 [1.8, 4.6]	63.5 [45.0, 64.0]	25.2 ± 25.2	24.0	2.3 [2.3, 8.9]	117 [111, 117]
Progesterone metabolites
Pregnenolone	14.2 ± 10.0	12.5	2.8 [2.6, 4.2]	53.0 [41.3, 54]	18.0 ± 14.7	14.9	1.9 [1.9, 3.3]	65.3 [57.3, 65.5]	27.9 ± 42.4	16.9	4.2 [4.2, 6.2]	265 [94.2, 265]
17-Hydroxypregnanolone	91.0 ± 76.4	79.5	14.6 [9.1, 23.1]	229 [202, 599]	88.3 ± 55.5	72.8	18.8 [18.7, 41.9]	247 [238, 247]	189 ± 253	113	34.1 [34.2, 50.6]	1298 1051, 1298]
Pregnanediol	1269 ± 830	1110	215 [154, 416]	4257 [3093, 4405]	1765 ± 1291	1461	459 [457, 633]	7514 [4181, 7602]	3982 ± 3762	2877	785 [779, 1162]	21112 [11216, 21112]
Pregnanetriol	209 ± 114	191	53.9 [34.2, 80.9]	455 [378, 774]	182 ± 94.0	153	35.8 [34.6, 99.6]	480 [443, 481]	287 ± 321	191	53.9 [53.4, 89.2]	1865 [970, 1865]
11-Oxopregnanetriol	2.7 ± 2.7	2.0	0.4 [0.3, 0.7]	11.8 [10.5, 14.7]	2.8 ± 4.4	1.5	0.3 [0.3, 0.7]	26.4 [10.0, 26.9]	11.3 ± 29.2	1.9	0.2 [0.2, 0.5]	151 [99.2, 1501]

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