Table 2 Steroid hormone metabolite[μg/mmol urinary creatinine]
1st trimester (n = 81) | 2nd trimester (n = 40) | 3rd trimester (n = 40) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Reference intervals | Reference intervals | Reference intervals | ||||||||||
move to a separate row | Mean ± SD | Median | 2.5th percentile [90 % CI] | 97.5th percentile [90 % CI] | Mean ± SD | Median | 2.5th percentile [90 % CI] | 97.5th percentile [90 % CI] | Mean ± SD | Median | 2.5th percentile [90 % CI] | 97.5th percentile [90 % CI] |
Androsterone | 322 ± 196 | 289 | 40.0 [36.0, 91.7] | 764 [740, 780] | 209 ± 172 | 159 | 17.3 [16.6, 55.5] | 746 [665, 748] | 237 ± 274 | 134 | 5.9 [5.5, 38.0] | 1409 [844, 1423] |
Etiocholanolone | 231 ± 141 | 211 | 31.0 [30.9, 65.3] | 617 [542, 688] | 149 ± 95.4 | 126 | 24.0 [23.7, 61.5] | 518 [355, 522] | 163 ± 176 | 108 | 6.5 [6.0, 34.9] | 774 [707, 776] |
11-Oxo-Etiocholanolon | 38.6 ± 18.7 | 37.6 | 6.3 [1.7, 11.5] | 84.4 [74.1, 87.0] | 38.0 ± 19.0 | 35.1 | 6.4 [6.3, 15.3] | 77.8 [72.7, 77.9] | 49.1 ± 52.3 | 36.7 | 5.8 [5.8, 13.5] | 325 [125, 325] |
11β-Hydroxy-Androsterone | 89.8 ± 53.3 | 75.1 | 20.8 [17.1, 23.1] | 233 [212, 234] | 70.8 ± 44.3 | 62.6 | 7.3 [7.1, 21.2] | 192 [188, 193] | 94.3 ± 123 | 58.7 | 4.9 [4.5, 21.4] | 716 [315, 726] |
11β-Hydroxy-Etiocholanolon | 31.5 ± 22.1 | 29.3 | 5.7 [4.8, 8.6] | 83.8 [65.3, 163] | 39.5 ± 28.6 | 28.6 | 3.2 [3.1, 11.6] | 112 [97.7, 112] | 43.4 ± 28.8 | 37.0 | 10.6 [10.5, 12.7] | 141 [105, 141] |
Dehydroepiandrosterone | 86.2 ± 158 | 23.1 | 1.5 [1.5, 4.4] | 759 [569, 774] | 49.6 ± 87.5 | 18.4 | 0.7 [0.7, 2.1] | 380 [348, 380] | 61.6 ± 167 | 12.0 | 1.3 [1.3, 2.5] | 919 [520, 929] |
5-Androstene-3β,17β-diol | 26.8 ± 25.6 | 18.8 | 1.4 [0.9, 4.1] | 125 [78.0, 144] | 20.1 ± 16.1 | 16.0 | 0.9 [0.9, 5.1] | 85.3 [55.2, 86] | 25.5 ± 29.8 | 17.9 | 1.0 [1.0, 5.5] | 175 [69.0, 175] |
5-Androstene-3β,17β-triol | 17.3 ± 57.2 | 5.3 | 0.7 [0.7, 1.8] | 225 [92.6, 454] | 10.9 ± 33.0 | 2.6 | 0.8 [0.8, 1.0] | 164 [139, 165] | 9.9 ± 20.8 | 2.6 | 0.7 [0.7, 0.9] | 115 [51.5, 115] |
16α-Hydroxy-dehydroepiandrostrerone | 96.4 ± 101 | 60.7 | 2.9 [1.2, 14.4] | 415 [277, 600] | 107 ± 107 | 88.7 | 2.1 [2.0, 12.5] | 569 [259, 577] | 154 ± 340 | 77.5 | 3.4 [3.3, 13.0] | 2139 [376, 2139] |
5-Androstene-3β,16α,17β-triol | 84.3 ± 75.0 | 55.8 | 9.2 [7.5, 22.2] | 278 [209, 306] | 65.4 ± 60.0 | 52.8 | 11.7 [11.7, 27.7] | 313 [127, 317] | 107 ± 155 | 60.2 | 12.4 [12.3, 18.5] | 868 [454, 868] |
5-Pregnene-3β,16α,17,20α-triol | 48.2 ± 56.5 | 36.8 | 1.2 [0.9, 3.5] | 317 [161, 397] | 20.6 ± 25.5 | 13.6 | 0.9 [0.9, 2.1] | 151 [50.7, 154] | 38.1 ± 111 | 11.4 | 1.7 [1.7, 2.9] | 690 [107, 690] |
Testosterone | 2.0 ± 1.8 | 1.6 | 0.3 [0.2, 0.5] | 9.4 [6, 11.1] | 2.4 ± 3.2 | 1.3 | 0.3 [0.3, 0.4] | 18.5 [7.4, 18.8] | 3.6 ± 5.6 | 2.0 | 0.5 [0.5, 0.7] | 27.8 [27.8, 28.1] |
5α-Dihydrotestosterone | 4.6 ± 3.2 | 3.6 | 0.6 [0.5, 1.1] | 12.3 [11.4, 12.9] | 3.7 ± 2.6 | 3.2 | 0.5 [0.5, 1.2] | 11.1 [10.1, 11.1] | 5.7 ± 3.7 | 4.6 | 0.4 [0.4, 1.7] | 19.1 [11.3, 19.3] |