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Table 2 Steroid hormone metabolite[μg/mmol urinary creatinine]

From: Gestation-specific reference intervals for comprehensive spot urinary steroid hormone metabolite analysis in normal singleton pregnancy and 6 weeks postpartum

  1st trimester (n = 81) 2nd trimester (n = 40) 3rd trimester (n = 40)
   Reference intervals    Reference intervals    Reference intervals
move to a separate row Mean ± SD Median 2.5th percentile [90 % CI] 97.5th percentile [90 % CI] Mean ± SD Median 2.5th percentile [90 % CI] 97.5th percentile [90 % CI] Mean ± SD Median 2.5th percentile [90 % CI] 97.5th percentile [90 % CI]
Androsterone 322 ± 196 289 40.0 [36.0, 91.7] 764 [740, 780] 209 ± 172 159 17.3 [16.6, 55.5] 746 [665, 748] 237 ± 274 134 5.9 [5.5, 38.0] 1409 [844, 1423]
Etiocholanolone 231 ± 141 211 31.0 [30.9, 65.3] 617 [542, 688] 149 ± 95.4 126 24.0 [23.7, 61.5] 518 [355, 522] 163 ± 176 108 6.5 [6.0, 34.9] 774 [707, 776]
11-Oxo-Etiocholanolon 38.6 ± 18.7 37.6 6.3 [1.7, 11.5] 84.4 [74.1, 87.0] 38.0 ± 19.0 35.1 6.4 [6.3, 15.3] 77.8 [72.7, 77.9] 49.1 ± 52.3 36.7 5.8 [5.8, 13.5] 325 [125, 325]
11β-Hydroxy-Androsterone 89.8 ± 53.3 75.1 20.8 [17.1, 23.1] 233 [212, 234] 70.8 ± 44.3 62.6 7.3 [7.1, 21.2] 192 [188, 193] 94.3 ± 123 58.7 4.9 [4.5, 21.4] 716 [315, 726]
11β-Hydroxy-Etiocholanolon 31.5 ± 22.1 29.3 5.7 [4.8, 8.6] 83.8 [65.3, 163] 39.5 ± 28.6 28.6 3.2 [3.1, 11.6] 112 [97.7, 112] 43.4 ± 28.8 37.0 10.6 [10.5, 12.7] 141 [105, 141]
Dehydroepiandrosterone 86.2 ± 158 23.1 1.5 [1.5, 4.4] 759 [569, 774] 49.6 ± 87.5 18.4 0.7 [0.7, 2.1] 380 [348, 380] 61.6 ± 167 12.0 1.3 [1.3, 2.5] 919 [520, 929]
5-Androstene-3β,17β-diol 26.8 ± 25.6 18.8 1.4 [0.9, 4.1] 125 [78.0, 144] 20.1 ± 16.1 16.0 0.9 [0.9, 5.1] 85.3 [55.2, 86] 25.5 ± 29.8 17.9 1.0 [1.0, 5.5] 175 [69.0, 175]
5-Androstene-3β,17β-triol 17.3 ± 57.2 5.3 0.7 [0.7, 1.8] 225 [92.6, 454] 10.9 ± 33.0 2.6 0.8 [0.8, 1.0] 164 [139, 165] 9.9 ± 20.8 2.6 0.7 [0.7, 0.9] 115 [51.5, 115]
16α-Hydroxy-dehydroepiandrostrerone 96.4 ± 101 60.7 2.9 [1.2, 14.4] 415 [277, 600] 107 ± 107 88.7 2.1 [2.0, 12.5] 569 [259, 577] 154 ± 340 77.5 3.4 [3.3, 13.0] 2139 [376, 2139]
5-Androstene-3β,16α,17β-triol 84.3 ± 75.0 55.8 9.2 [7.5, 22.2] 278 [209, 306] 65.4 ± 60.0 52.8 11.7 [11.7, 27.7] 313 [127, 317] 107 ± 155 60.2 12.4 [12.3, 18.5] 868 [454, 868]
5-Pregnene-3β,16α,17,20α-triol 48.2 ± 56.5 36.8 1.2 [0.9, 3.5] 317 [161, 397] 20.6 ± 25.5 13.6 0.9 [0.9, 2.1] 151 [50.7, 154] 38.1 ± 111 11.4 1.7 [1.7, 2.9] 690 [107, 690]
Testosterone 2.0 ± 1.8 1.6 0.3 [0.2, 0.5] 9.4 [6, 11.1] 2.4 ± 3.2 1.3 0.3 [0.3, 0.4] 18.5 [7.4, 18.8] 3.6 ± 5.6 2.0 0.5 [0.5, 0.7] 27.8 [27.8, 28.1]
5α-Dihydrotestosterone 4.6 ± 3.2 3.6 0.6 [0.5, 1.1] 12.3 [11.4, 12.9] 3.7 ± 2.6 3.2 0.5 [0.5, 1.2] 11.1 [10.1, 11.1] 5.7 ± 3.7 4.6 0.4 [0.4, 1.7] 19.1 [11.3, 19.3]