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Table 4 MMP and TIMP activities in the follicular fluid between high and low D5 GB embryo groups

From: Matrix metalloproteinase 2 level in human follicular fluid is a reliable marker of human oocyte maturation in in vitro fertilization and intracytoplasmic sperm injection cycles

  High D5 GB group (D5 GB ≥ 50 %) Low D5 GB group (D5 GB < 50 %) P value
Number of patients 59 91  
Estradiol (pg/ml) 2937 ± 1362 2541 ± 1715 NS
Progesterone (ng/ml) 0.83 ± 0.76 0.68 ± 0.36 NS
MII oocytes ratio (%) 89.7 ± 14.6 92.4 ± 15.0 NS
2PN embryos ratio (%) 77.0 ± 21.0 67.7 ± 25.5 < 0.05
D5 GB embryos ratio (%) 72.4 ± 16.3 11.8 ± 16.5 < 0.001
MMP-2 (Arbitrary units/μl) 17.2 ± 4.3 19.1 ± 4.5 NS
MMP-9 (Arbitrary units/μl) 2.25 ± 0.66 2.04 ± 0.63 NS
TIMP-1 (ng/ml) 114 ± 30 120 ± 36 NS
TIMP-2 (ng/ml) 54.9 ± 14.8 54.3 ± 16.1 NS
  1. MII Metaphase II, 2PN Two pronuclei, D5 GB Good-quality blastocysts on day 5, MMP Matrix metalloproteinase, TIMP Tissue inhibitor of matrix metalloproteinase
  2. Values are expressed as the means ± SD. P values are comparisons between the high and low D5 GB embryo groups by ANOVA.; NS: no statistical significance (i.e., P > 0.05)