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Table 2 MMP and TIMP activities in the follicular fluid between high and low oocyte maturity groups

From: Matrix metalloproteinase 2 level in human follicular fluid is a reliable marker of human oocyte maturation in in vitro fertilization and intracytoplasmic sperm injection cycles

  High oocyte maturity group (MII oocytes = 100 %) Low oocyte maturity group (MII oocytes < 100 %) P value
Number of patients 95 55  
Estradiol (pg/ml) 2774 ± 1078 2651 ± 1829 NS
Progesterone (ng/ml) 0.81 ± 0.78 0.69 ± 0.39 NS
MII oocytes ratio (%) 100 ± 0 76.4 ± 15.8 < 0.001
2PN embryos ratio (%) 75.9 ± 24.4 68.8 ± 23.8 NS
D5 GB embryos ratio (%) 45.8 ± 32.5 29.8 ± 33.5 < 0.01
MMP-2 (Arbitrary units/μl) 19.6 ± 4.3 16.3 ± 4.3 < 0.001
MMP-9 (Arbitrary units/μl) 2.11 ± 0.59 2.19 ± 0.74 NS
TIMP-1 (ng/ml) 123 ± 37 107 ± 26 NS
TIMP-2 (ng/ml) 54.6 ± 16.5 52.6 ± 13.6 NS
  1. MII Metaphase II, 2PN Two pronuclei, D5 GB Good-quality blastocysts on day 5, MMP Matrix metalloproteinase, TIMP Tissue inhibitor of matrix metalloproteinase
  2. Values are expressed as the mean ± SD. P values are comparisons between the high- and low-maturity groups by ANOVA.; NS: no statistical significance (i.e., P > 0.05)