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Table 2 Biological and clinical outcomes of two study arms

From: RETRACTED ARTICLE: Intracytoplasmic morphologically selected sperm injection versus conventional intracytoplasmic sperm injection: a randomized controlled trial

 

IMSI (n. 48)

cICSI (n. 73)

P

Sperm count (million/ml)

22.6 ± 24.6

22.9 ± 23.7

0.947

Motility (% total count)

29.6 ± 16.0

24.5 ± 12.8

0.055

Morphologically normal spermatozoa (% total count)

2.9 ± 2.2

2.8 ± 2.3

0.812

Sperm morphology by MSOME criteria (n., %)

Normal nuclei

160/219; 73.0

---

---

First choice selected sperm

33/219; 15.1

---

---

Second choice selected sperm

21/219; 9.6

---

---

Third choice selected sperm

5/219; 2.3

---

---

Aspirated cycles (n.)

48

73

---

Retrieved oocytes (n.)

6.3 ± 2.7

6 ± 3.5

0.6157

MII oocytes retrieved (n.)

5.1 ± 2.5

5.3 ± 3.1

0.709

Oocytes inseminated (n.)

4.6 ± 1.9

4.6 ± 2.8

1.000

Fertilization rate (n.; %)

105/219; 47.9

211/333; 63.4

0.001

Embryo obtained (n.)

99, 2.1 ± 1.7

221, 3.0 ± 1.9

0.009

Good quality embryos rate (n.; %)

73/99; 73.7

167/221; 75.6

0.834

ET rate (n.; %)

34/48; 70.8

64/73; 87.7

0.038

Embryo transferred (n.)

65, 1.4 ± 1.0

137, 1.9 ± 1.2

0.018

Implantation rate (n.; %)

15/65; 23.1

18/137; 13.1

0.102

Total pregnancies (n.)

14

19

---

Total pregnancy rate//initiated cycles (n.; %)a

14/48; 29.2

19/73; 26.0

0.865

Total pregnancy rate/ET (n.; %)

14/34; 41.2

19/64; 29.7

0.952

OHSS rate (n.; %)

5/48; 10.4

6/73; 8.2

0.930

Biochemical pregnancy rate (n., %)

3/14; 21.4

4/19; 21.1

0.859

Clinical pregnancies (n.)

11

15

---

Clinical pregnancy rate/initiated cycles (n.; %)*

11/48; 22.9

15/73; 20.5

0.823

Clinical pregnancy rate/ET rate (n.; %)

11/34; 32.3

15/64; 23.4

0.349

Miscarriage rate (n.; %)

2/11; 18.2

4/15; 26.7

1.000

Multiple pregnancies rate (n.; %)

4/11; 36.4

4/15; 26.7

0.683

Delivery live births (n.)

9

11

---

Delivery live birth rate/initiated cycles (n.; %)*

9/48; 18.8

11/73; 15.1

0.624

Delivery live birth rate/ET (n.; %)

9/34; 26.5

11/64; 17.2

0.301

Twin deliveries

2/9; 22.2

4/11; 36.4

0.496

Live births

11

14

 

Cycles with embryo freezing

9/48; 18.8

13/73; 17.8

0.895

Embryo thawing cycles

9

7

----

Embryo thawing ET

6/9; 66.7

5/7; 71.4

0.839

Embryo thawing clinical pregnancies

0/6; 0

2/5; 40

0.186

Embryo thawing deliveries

0/6

1/5; 20

0.528

Total delivery live birth rate/initiated cycle (n., %)

9/48; 18.8

12/73; 16.4

0.743

  1. Data expressed as mean ± SD or as number/percentage. MII metaphase II, MOSOME motile sperm organelle morphology examination, PU pick-up, ET embryo transfer, OHSS ovarian hyperstimulation syndrome, aBecause no cycle was cancelled, the initialled cycles corresponded to the aspirated cycles