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Fig. 4 | Reproductive Biology and Endocrinology

Fig. 4

From: The HDL receptor SR-BI is associated with human prostate cancer progression and plays a possible role in establishing androgen independence

Fig. 4

Correlation of SR-BI with androgen-synthesizing enzymes and the mTOR pathway. Differential expression of HSD17B1 and HSD3B1 in primary tumors (primary site) and metastasizing tumors (metastasis) (a, c, e, g). The arithmetic mean is given as a line within the dots and the P-values of t-test analysis is given within each graph. Scatter plots correlating SR-BI expression with HSD17B1 and HSD3B1 in prostate cancer (b, d, f, h). P-values of Pearson correlation analyses and regression lines are presented within each graph. Red dots represent metastatic and blue dots represent non-metastatic prostate cancer. Analysis of the co-occurrence of SR-BI and ribosomal protein S6 phosphorylation (i–l). A representative high grade prostate cancer is shown with staining for SR-BI (i) and for S6 phosphorylation at serine 240 and 244 in a consecutive area of the same tumor (j). A representative low grade prostate cancer is shown with staining for SR-BI (k) and for S6 phosphorylation at serine 240 and 244 in a consecutive area of the same tumor (l). pS6 = ribosomal protein S6 phosphorylation at serine 240 and 244

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