Fig. 2

Immunohistochemical staining of prostate tissue and control tissue for SR-BI expression. Each panel shows representative prostate samples scored for staining intensity as follows: 0 for negative (a), 1 for low (b), 2 for moderate (c) and 3 for high (d). Liver sections were used as positive controls (pos. ctrl.) in standard magnification (e) and in high magnification (high mag.), demonstrating SR-BI localization in the outer cell membrane of hepatocytes (f). The overall scoring distribution for SR-BI staining intensity in different clinicopathological groups (g). Scores of 0 and 1 represented “low” expression and are shown in green colors, whereas scores of 2 and 3 represented “high” expression and are shown in blue colors. Clinicopathological groups are plotted on the x-axis: non-cancer and cancer, Gleason score (GS) ≤ 6 and ≥ 7, pathologic tumor stage 2 (pT2) and pathologic tumor stage 3/4 (pT3/4), metastasis negative (met. neg.) and metastasis positive (met. pos.)