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Table 4 Individual association of cycle parameters with pregnancy rate, clinical pregnancy rate and live birth rate

From: Maximum basal FSH predicts reproductive outcome better than cycle-specific basal FSH levels: waiting for a “better" month conveys limited retrieval benefits

  

Pregnancy rate

  

Clinical Pregnancy rate

  

Live Birth rate

  

Parameter

Compared with

Odds ratio

95 % CI

Sig.

Odds ratio

95 % CI

Sig.

Odds ratio

95 % CI

Sig.

Age Group B

Age Group A

0.79

[0.65,0.96]

*

0.81

[0.67,0.97]

*

0.81

[0.67,0.99]

*

Age Group C

Age Group A

0.58

[0.48,0.70]

***

0.54

[0.45,0.65]

***

0.46

[0.38,0.56]

***

Age Group D

Age Group A

0.46

[0.37,0.57]

***

0.37

[0.30,0.46]

***

0.31

[0.24,0.39]

***

Age Group E

Age Group A

0.19

[0.15,0.25]

***

0.13

[0.10,0.19]

***

0.09

[0.06,0.14]

***

Downregulation Protocol

Antagonist Protocol

1.65

[1.33,2.06]

***

1.73

[1.41,2.13]

***

1.62

[1.31,2.01]

***

Microflare Protocol

Antagonist Protocol

0.75

[0.64,0.89]

**

0.73

[0.61,0.87]

***

0.73

[0.60,0.89]

**

IVF Cycle 2

IVF Cycle 1

0.87

[0.75,1.00]

 

0.90

[0.78,1.04]

 

0.91

[0.78,1.07]

 

IVF Cycle 3

IVF Cycle 1

0.91

[0.73,1.13]

 

0.88

[0.70,1.10]

 

0.81

[0.63,1.03]

 

IVF Cycle 4

IVF Cycle 1

0.81

[0.57,1.13]

 

0.71

[0.50,1.01]

 

0.57

[0.39,0.85]

**

IVF Cycle 5+

IVF Cycle 1

0.82

[0.54,1.24]

 

0.73

[0.48,1.11]

 

0.68

[0.41,1.13]

 

Previous MII Count

Per Oocyte

1.04

[1.02,1.07]

***

1.05

[1.03,1.07]

***

1.03

[1.01,1.05]

**

E2 Surge Level

Per 1000 pg/mL

1.32

[1.23,1.41]

***

1.31

[1.23,1.40]

***

1.24

[1.15,1.33]

***

Previous E2 Surge Level

Per 1000 pg/mL

1.16

[1.03,1.31]

*

1.20

[1.06,1.36]

**

1.11

[0.98,1.27]

 

Total Gonadotropin Dosage

Per 1000 IU

0.79

[0.75,0.83]

***

0.76

[0.72,0.80]

***

0.76

[0.71,0.80]

***

Previous Total Gonadotropin Dosage

Per 1000 IU

0.89

[0.82,0.96]

**

0.82

[0.75,0.89]

***

0.81

[0.74,0.89]

***

AMH

Per 1 ng/mL

1.14

[1.04,1.26]

**

1.15

[1.05,1.26]

**

1.08

[0.99,1.17]

 

Day 5 Transfer

Day 3 Transfer

1.58

[1.36,1.84]

***

1.70

[1.47,1.97]

***

1.75

[1.50,2.03]

***

Day 6 Transfer

Day 3 Transfer

1.57

[1.04,2.38]

*

1.58

[1.06,2.36]

*

1.67

[1.11,2.50]

*

2 Embryos Transferred

1 Embryo Transferred

2.41

[1.97,2.94]

***

2.49

[2.02,3.06]

***

2.46

[1.97,3.06]

***

3 Embryos Transferred

1 Embryo Transferred

2.60

[2.08,3.24]

***

2.41

[1.92,3.02]

***

2.01

[1.59,2.56]

***

4 Embryos Transferred

1 Embryo Transferred

2.02

[1.55,2.64]

***

2.03

[1.55,2.66]

***

1.97

[1.49,2.61]

***

5+ Embryos Transferred

1 Embryo Transferred

2.56

[1.88,3.49]

***

2.05

[1.50,2.81]

***

1.71

[1.24,2.35]

***

ICSI

Conventional IVF

0.95

[0.83,1.09]

 

1.00

[0.87,1.15]

 

1.11

[0.96,1.28]

 

Max FSH

Per 1 mIU/mL

0.93

[0.91,0.95]

***

0.93

[0.91,0.95]

***

0.94

[0.92,0.96]

***

PMax FSH

Per 1 mIU/mL

0.93

[0.92,0.95]

***

0.93

[0.91,0.95]

***

0.94

[0.92,0.96]

***

Current FSH

Per 1 mIU/mL

0.94

[0.92,0.96]

***

0.94

[0.92,0.96]

***

0.95

[0.93,0.97]

***

Max FSH Observed 1 Month Ago

0 Months Ago

1.28

[1.06,1.54]

*

1.31

[1.08,1.58]

**

1.18

[0.97,1.45]

 

Max FSH Observed 2 Months Ago

0 Months Ago

1.01

[0.79,1.30]

 

0.93

[0.72,1.20]

 

0.87

[0.66,1.15]

 

Max FSH Observed 2-6 Months Ago

0 Months Ago

0.99

[0.82,1.20]

 

1.00

[0.83,1.21]

 

0.93

[0.76,1.14]

 

Max FSH Observed >6 Months Ago

0 Months Ago

1.12

[0.93,1.35]

 

1.20

[0.99,1.44]

 

1.10

[0.91,1.35]

 
  1. A GEE model controlling for patient and cycle number was constructed to test the association of multiple clinical parameters with pregnancy rate, clinical pregnancy rate or live birth rate. Association was noted as odds ratio (OR) with 95 % confidence intervals. Model significance was noted as ***(p<0.001), **(p<0.01) or *(p<0.05)
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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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