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Table 4 Individual association of cycle parameters with pregnancy rate, clinical pregnancy rate and live birth rate

From: Maximum basal FSH predicts reproductive outcome better than cycle-specific basal FSH levels: waiting for a “better" month conveys limited retrieval benefits

   Pregnancy rate    Clinical Pregnancy rate    Live Birth rate   
Parameter Compared with Odds ratio 95 % CI Sig. Odds ratio 95 % CI Sig. Odds ratio 95 % CI Sig.
Age Group B Age Group A 0.79 [0.65,0.96] * 0.81 [0.67,0.97] * 0.81 [0.67,0.99] *
Age Group C Age Group A 0.58 [0.48,0.70] *** 0.54 [0.45,0.65] *** 0.46 [0.38,0.56] ***
Age Group D Age Group A 0.46 [0.37,0.57] *** 0.37 [0.30,0.46] *** 0.31 [0.24,0.39] ***
Age Group E Age Group A 0.19 [0.15,0.25] *** 0.13 [0.10,0.19] *** 0.09 [0.06,0.14] ***
Downregulation Protocol Antagonist Protocol 1.65 [1.33,2.06] *** 1.73 [1.41,2.13] *** 1.62 [1.31,2.01] ***
Microflare Protocol Antagonist Protocol 0.75 [0.64,0.89] ** 0.73 [0.61,0.87] *** 0.73 [0.60,0.89] **
IVF Cycle 2 IVF Cycle 1 0.87 [0.75,1.00]   0.90 [0.78,1.04]   0.91 [0.78,1.07]  
IVF Cycle 3 IVF Cycle 1 0.91 [0.73,1.13]   0.88 [0.70,1.10]   0.81 [0.63,1.03]  
IVF Cycle 4 IVF Cycle 1 0.81 [0.57,1.13]   0.71 [0.50,1.01]   0.57 [0.39,0.85] **
IVF Cycle 5+ IVF Cycle 1 0.82 [0.54,1.24]   0.73 [0.48,1.11]   0.68 [0.41,1.13]  
Previous MII Count Per Oocyte 1.04 [1.02,1.07] *** 1.05 [1.03,1.07] *** 1.03 [1.01,1.05] **
E2 Surge Level Per 1000 pg/mL 1.32 [1.23,1.41] *** 1.31 [1.23,1.40] *** 1.24 [1.15,1.33] ***
Previous E2 Surge Level Per 1000 pg/mL 1.16 [1.03,1.31] * 1.20 [1.06,1.36] ** 1.11 [0.98,1.27]  
Total Gonadotropin Dosage Per 1000 IU 0.79 [0.75,0.83] *** 0.76 [0.72,0.80] *** 0.76 [0.71,0.80] ***
Previous Total Gonadotropin Dosage Per 1000 IU 0.89 [0.82,0.96] ** 0.82 [0.75,0.89] *** 0.81 [0.74,0.89] ***
AMH Per 1 ng/mL 1.14 [1.04,1.26] ** 1.15 [1.05,1.26] ** 1.08 [0.99,1.17]  
Day 5 Transfer Day 3 Transfer 1.58 [1.36,1.84] *** 1.70 [1.47,1.97] *** 1.75 [1.50,2.03] ***
Day 6 Transfer Day 3 Transfer 1.57 [1.04,2.38] * 1.58 [1.06,2.36] * 1.67 [1.11,2.50] *
2 Embryos Transferred 1 Embryo Transferred 2.41 [1.97,2.94] *** 2.49 [2.02,3.06] *** 2.46 [1.97,3.06] ***
3 Embryos Transferred 1 Embryo Transferred 2.60 [2.08,3.24] *** 2.41 [1.92,3.02] *** 2.01 [1.59,2.56] ***
4 Embryos Transferred 1 Embryo Transferred 2.02 [1.55,2.64] *** 2.03 [1.55,2.66] *** 1.97 [1.49,2.61] ***
5+ Embryos Transferred 1 Embryo Transferred 2.56 [1.88,3.49] *** 2.05 [1.50,2.81] *** 1.71 [1.24,2.35] ***
ICSI Conventional IVF 0.95 [0.83,1.09]   1.00 [0.87,1.15]   1.11 [0.96,1.28]  
Max FSH Per 1 mIU/mL 0.93 [0.91,0.95] *** 0.93 [0.91,0.95] *** 0.94 [0.92,0.96] ***
PMax FSH Per 1 mIU/mL 0.93 [0.92,0.95] *** 0.93 [0.91,0.95] *** 0.94 [0.92,0.96] ***
Current FSH Per 1 mIU/mL 0.94 [0.92,0.96] *** 0.94 [0.92,0.96] *** 0.95 [0.93,0.97] ***
Max FSH Observed 1 Month Ago 0 Months Ago 1.28 [1.06,1.54] * 1.31 [1.08,1.58] ** 1.18 [0.97,1.45]  
Max FSH Observed 2 Months Ago 0 Months Ago 1.01 [0.79,1.30]   0.93 [0.72,1.20]   0.87 [0.66,1.15]  
Max FSH Observed 2-6 Months Ago 0 Months Ago 0.99 [0.82,1.20]   1.00 [0.83,1.21]   0.93 [0.76,1.14]  
Max FSH Observed >6 Months Ago 0 Months Ago 1.12 [0.93,1.35]   1.20 [0.99,1.44]   1.10 [0.91,1.35]  
  1. A GEE model controlling for patient and cycle number was constructed to test the association of multiple clinical parameters with pregnancy rate, clinical pregnancy rate or live birth rate. Association was noted as odds ratio (OR) with 95 % confidence intervals. Model significance was noted as ***(p<0.001), **(p<0.01) or *(p<0.05)
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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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