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Table 4 Most highly up- and down-regulated DEGs within epithelial cells of the isthmus in follicular phase versus luteal phase groups (FDR adjusted P < 0.05)

From: A transcriptomal analysis of bovine oviductal epithelial cells collected during the follicular phase versus the luteal phase of the estrous cycle

Gene Symbol Gene Description P-value Fold-Change
 KRT23 keratin 23 (histone deacetylase inducible) <0.001 22.57
 NTS neurotensin <0.001 21.57
 PRND prion protein 2 (dublet) <0.001 12.36
 STRA6 stimulated by retinoic acid gene 6 homolog (mouse) <0.001 11.22
 TMEM45A transmembrane protein 45A 0.004 10.56
 PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 0.004 9.86
 LPL lipoprotein lipase <0.001 9.40
 SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 <0.001 8.92
 CLEC3A C-type lectin domain family 3, member A <0.001 8.69
 GFAP glial fibrillary acidic protein <0.001 8.09
 CRELD2 cysteine-rich with EGF-like domains 2 <0.001 7.69
 CA2 carbonic anhydrase II <0.001 7.68
 PLA2G4D phospholipase A2, group IVD (cytosolic) <0.001 7.64
 CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 0.001 7.34
 SDF2L1 stromal cell-derived factor 2-like 1 <0.001 7.31
 PPP2R2C protein phosphatase 2, regulatory subunit B, gamma 0.000 7.30
 P2RX2 purinergic receptor P2X, ligand-gated ion channel, 2 0.002 6.86
 PLA2G4F phospholipase A2, group IVF <0.001 6.85
 SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 <0.001 6.69
 CDC20B cell division cycle 20 homolog B (S. cerevisiae) 0.001 6.35
Gene Symbol Gene Description P-value Fold-Change
 KLF17 Kruppel-like factor 17 <0.001 −14.70
 KSR2 kinase suppressor of ras 2 <0.001 −8.94
 LOC100337391 predicted protein-like <0.001 −7.77
 BSP3 binder of sperm 3 <0.001 −7.58
 OR9Q2 olfactory receptor, family 9, subfamily Q, member 2 0.001 −6.87
 ZBTB16 zinc finger and BTB domain containing 16 <0.001 −5.91
 EGR1 early growth response 1 0.019 −5.35
 LOC522479 ovalbumin-like <0.001 −5.34
 CWH43 cell wall biogenesis 43 C-terminal homolog (S. cerevisiae) 0.001 −5.09
 TFF3 trefoil factor 3 (intestinal) <0.001 −4.98
 LOC100335668 mitochondrial import inner membrane translocase subunit Tim9 pseudogene 0.001 −4.94
 LOC617981 family with sequence similarity 55, member C-like <0.001 −4.92
 MEGF10 multiple EGF-like-domains 10 <0.001 −4.81
 LOC100337183 contactin associated protein-like 3-like 0.003 −4.75
 AK5 adenylate kinase 5 <0.001 −4.74
 FOS FBJ murine osteosarcoma viral oncogene homolog 0.012 −4.54
 CA10 carbonic anhydrase X 0.001 −4.40
 NDP Norrie disease (pseudoglioma) <0.001 −4.34
 SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1- like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A <0.001 −4.26
 CAV1 caveolin 1, caveolae protein, 22 kDa 0.003 −4.14
  1. For statistical analysis, an F-test on least-square means was used to determine significance of each transcript in each comparison. Benjamini-hochberg multiple testing correction for false discovery rate (FDR) was applied and significance set to FDR adjusted P-value < 0.05. A post-hoc pairwise comparison of FP compared to LP epithelial cells from the isthmus was completed using Fisher’s Least Significant Difference (LSD) to determine which means differed