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Table 3 Most highly up- and down-regulated DEGs within epithelial cells of the ampulla in follicular versus luteal phase groups (FDR adjusted P < 0.05)

From: A transcriptomal analysis of bovine oviductal epithelial cells collected during the follicular phase versus the luteal phase of the estrous cycle

Gene Symbol Gene description P-value Fold-Change
 NTS Neurotensin <0.001 32.44
 PRND prion protein 2 (dublet) <0.001 18.30
 CDC20B cell division cycle 20 homolog B (S. cerevisiae) <0.001 17.49
 bTrappin-5 trappin 5 <0.001 11.14
 TMEM45A transmembrane protein 45A 0.004 10.69
 CRELD2 cysteine-rich with EGF-like domains 2 <0.001 9.98
 SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 <0.001 9.54
 SDF2L1 stromal cell-derived factor 2-like 1 <0.001 9.29
 MIR449C microRNA mir-449c <0.001 9.20
 KRT23 keratin 23 (histone deacetylase inducible) 0.004 8.40
 DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 <0.001 6.92
 MANF mesencephalic astrocyte-derived neurotrophic factor <0.001 6.90
 MFSD2A major facilitator superfamily domain containing 2A <0.001 6.70
 CLPH calcium-binding protein, spermatid-specific 1 (CABS1) <0.001 6.61
 PLA2G4D phospholipase A2, group IVD (cytosolic) <0.001 6.61
 CBLN4 cerebellin 4 precursor <0.001 6.57
 SERPINE3 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 <0.001 6.54
 RRM2 ribonucleotide reductase M2 <0.001 6.52
 H4 histone H4 <0.001 6.30
 INSIG1 insulin induced gene 1 <0.001 6.21
Gene Symbol Gene Description P-value Fold-Change
 EGR1 early growth response 1 0.005 −9.13
 FOS FBJ murine osteosarcoma viral oncogene homolog 0.002 −8.55
 VCAM1 vascular cell adhesion molecule 1 <0.001 −7.11
 GABRP gamma-aminobutyric acid (GABA) A receptor, pi <0.001 −6.76
 GPR174 G protein-coupled receptor 174 0.003 −5.15
 ZBTB16 zinc finger and BTB domain containing 16 0.001 −4.62
 BMP4 bone morphogenetic protein 4 0.001 −4.44
 LOC777601 uncharacterized LOC777601 <0.001 −4.37
 FIGF c-fos induced growth factor (vascular endothelial growth factor D) <0.001 −4.12
 KLRK1 killer cell lectin-like receptor subfamily K, member 1 0.003 −4.09
 PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.001 −3.93
 LOC100297676 C-type lectin domain family 2 member G-like 0.003 −3.78
 LOC100337183 contactin associated protein-like 3-like 0.008 −3.71
 LOC768255 GTPase, IMAP family member 4-like 0.001 −3.64
 TRAT1 T cell receptor associated transmembrane adaptor 1 0.007 −3.48
 CAPN6 calpain 6 0.007 −3.48
 CAV1 caveolin 1, caveolae protein, 22 kDa 0.005 −3.44
 LOC541007 Similar to protein jade-2(PHD finger protein 15) (BT24231-RA) <0.001 −3.34
 CHRDL1 chordin-like 1 0.002 −3.31
 MIR29C microRNA mir-29c 0.001 −3.29
  1. For statistical analysis, an F-test on least-square means was used to determine significance of each transcript in each comparison. Benjamini-hochberg multiple testing correction for false discovery rate 2 (FDR) was applied and significance set to FDR adjusted P-value < 0.05. A post-hoc pairwise comparison of FP compared to LP epithelial cells from the ampulla was completed using Fisher’s Least Significant Difference (LSD) to determine which means differed