Fig. 1From: The production of alpha/beta and gamma/delta double negative (DN) T-cells and their role in the maintenance of pregnancyProposed pathways for the production of T-cells in prepubertal mice. Progenitor cells enter the thymus via postcapillary venules (PCVs) located in the medulla and as T-cells leave by way of efferent lymphatic vessels (ELVs) located in the subcapsular cortex and in the medulla. In prepubertal mice, the majority of thymocytes traverse the classic developmental pathway and as SP T-cells enter the lymphatic system (LS) (solid black arrows) via ELVs located in the medulla. Lesser numbers of thymocytes enter the LS (dashed black arrows) as DN T-cells through ELVs located in the subscapular regionBack to article page