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Table 2 Embryological and clinical outcomes

From: Ovarian hyperstimulation syndrome: a clinical report on 4894 consecutive ART treatment cycles

Parameters HCG Buserelin OHSS p
Cycles 4772 71 51  
COC 36768 1134 563  
COC (mean) 7.8 ± 4.7 16.0 ± 6.9 11.0 ± 4.0 a,b,c
MII 30872 910 469  
Maturation rate (MII/COC) 84.0 80.2 83.3 a
2PN/2 PB 21410 648 346  
Fertilization rate (2PN/MII) 69.4 71.2 73.8 b
Embryos cleaved 20954 641 337  
Embryo cleavage rate (d2/2PN) 97.9 98.9 97.4 NS
Embryo transfer cycles (ETC.) 4391 67 51  
n° Embryos transferred (mean) 8443-1.9 ± 0.5 121-1.8 ± 0.4 92-1.8 ± 0.4 NS
Biochemical pregnancy (/ETC.) 1973-44.9 32-47.8 49-96.1 b,c
Clinical pregnancy (CP) (/ETC.) 1709-38.9 20-29.9 48-94.1 b,c
Sacs 2155 23 64  
Implantation rate (sacs/n°ET) 25.5 19.0 69.6 b,c
Singletons (/CP) 1197-70.0 9-45.0 29-60.4 a
Twins (/CP) 473-27.7 7-35.0 16-33.3 NS
Triplets (/CP) 11-0.6 0 1-2.1 NS
Ectopic pregnancy (/CP) 28-1.6 4-20.0 2-4.2 a,c
Abortion (/CP) 253-14.8 2-10.0 6-12.5 NS
Ongoing pregnancy (/ETC.) 1428-32.5 14-20.9 40-78.4 a,b,c
Delivery (/ETC.) 1329-30.3 14-20.9 40-78.4 b,c
Stillbirths (/ETC.) 1-0.02 0 0 NS
Live-birth delivery rate (/ETC.) 1328-30.2 14-20.9 40-78.4 b,c
Newborn (NB) (/ETC.) 1655-37.7 19-28.4 53-100 b,c
Male (/NB) 832-50.5 11-57.9 25-47.2 NS
Female (/NB) 817-49.5 8-42.1 28-52.8 NS
Male/Female ratio 1.0 1.4 0.90 NS
Newborn malformations (/NB) 36-2.2 2-10.5 0 a,c
Major (/NB) 27-1.6 2-10.5 0 a,c
Minor (/NB) 9-0.5 0 0 NS
NB Chromosome abnormalities (/NB) 5-0.3 0 0 NS
Early neonatal death (/ETC.) 4-0.1 0 0 NS
  1. Values in “n”, rate or mean ± SD
  2. Significance (p < 0.05)
  3. a: HCG vs Buserelin
  4. b: HCG vs OHSS
  5. c: Buserelin vs OHSS
  6. NS: not significant
  7. HCG: group of patients without OHSS and oocyte trigger with HCG
  8. Buserelin: group of patients without OHSS and oocyte trigger with Buserelin
  9. OHSS: group of patients with OHSS and oocyte trigger with HCG
  10. COC: cumulus-oocyte complexes (aspirated oocytes)
  11. MII: mature oocytes at metaphase II of meiosis
  12. 2PN/2 PB: normal fertilized oocytes (with 2 pronuclei and 2 polar bodies)