In the pubertal rat, the regulation of ovarian function involves the synergic participation of the sensory and sympathetic innervations that arrive at the gonad

Table 1 Age of vaginal opening (days)

Pharmacological procedure in new born and surgical procedure in 20-day-old rats
	Vehicle	Capsaicin
SO	38.4 ± 0.8	38.3 ± 0.9
SSON-L	37.3 ± 0.4	40.4 ± 0.8^a
SSON-R	37.5 ± 0.6	38.9 ± 1.0
SSON-B	36.9 ± 0.8	40.8 ± 1.0^b
Pharmacological procedure in new born and surgical procedure in 28-day-old rats
	Vehicle	Capsaicin
SO	37.4 ± 0.8	40.6 ± 0.9^c
SSON-L	37.3 ± 0.9	38.0 ± 0.7
SSON-R	37.7 ± 0.7	39.6 ± 1.2
SSON-B	39.9 ± 0.7	38.3 ± 0.6

Mean ± SEM of the age vaginal opening in animals treated with vehicle or capsaicin at birth and subject at section of the SON. At 20 or 28 days of age, the animals were subjected to a sham-operation (SO) or to left (L), right (R) or bilateral (B) SSON. All animals were sacrificed at the first vaginal estrus. Significance was noted as indicated. ^a p <0.05 CAPSAICIN + SSON-L vs. VEHICLE + SSON-L at 20 days old. ^b p <0.05 CAPSAICIN + SSON-B vs. VEHICLE + SSON-B at 20 days of age. ^c p <0.05 CAP + SO vs. VEHICLE + SO at 28 days of age; Kruskal-Wallis test followed by the Mann–Whitney test

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