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Table 5 The association analysis of the seven SNPs among the early amenorrhea, late amenorrhea and control groups

From: No association between polymorphisms in PTEN and primary ovarian insufficiency in a Han Chinese population

SNP Genotype, n (%) Value p Alleles Value P Bonferroni correction
rs1234219 T/T T/C C/C Missing   0.945 T C   0.810 1.000
Early amenorrhea 23 3 0 0 0.820 49 3 0.418
Late amenorrhea 101 20 1 0   222 22  
Controls 191 34 2 3   416 38  
rs1903858 C/C C/T T/T Missing   0.195 C T   0.168 1.000
Early amenorrhea 5 16 5 0 6.057 26 26 3.572
Late amenorrhea 42 54 26 0   138 106  
Controls 55 112 59 4   222 230  
rs2299939 C/C C/A A/A Missing   0.143 C A   0.044 0.308
Early amenorrhea 22 4 0 0 6.515 48 4 6.267
Late amenorrhea 84 35 2 1   203 39  
Controls 146 67 13 4   359 93  
rs35352882 T/T T/C C/C Missing   0.955 T C   0.957 1.000
Early amenorrhea 24 2 0 0 0.101 50 2 0.095
Late amenorrhea 111 11 0 0   233 11  
Controls 207 19 0 4   433 19  
rs17107001 G/G G/T T/T Missing   0.704 G T   0.711 1.000
Early amenorrhea 25 1 0 0 0.679 51 1 0.840
Late amenorrhea 112 10 0 0   234 10  
Controls 212 14 0 4   438 14  
rs2299941 A/A A/G G/G Missing   0.731 A G   0.776 1.000
Early amenorrhea 9 15 2 0 2.056 33 19 0.506
Late amenorrhea 47 57 18 0   151 93  
Controls 96 100 30 4   292 160  
rs12572106 T/T T/C C/C Missing   0.527 T C   0.352 1.000
Early amenorrhea 7 15 4 0 3.189 29 23 2.091
Late amenorrhea 40 56 26 0   136 108  
Controls 87 102 37 4   276 176  
  1. The allele and genotype frequencies among the early amenorrhea, late amenorrhea and control groups were performed with Pearson’s chi-squared test or Fisher’s exact test using SPSS 13.0 software. There was no statistically significant difference in the allelic and genotypic distributions between the early amenorrhea, late amenorrhea and control groups after Bonferroni correction