No association between polymorphisms in PTEN and primary ovarian insufficiency in a Han Chinese population

Table 3 The haplotype distributions of PTEN polymorphisms in POI patients and controls

Haplotype	Total frequency	Cases frequency	Controls frequency	p-value	p-value from permutation
T-C-C-G-C	0.358	0.378	0.345	0.355	0.820
T-T-C-A-T	0.302	0.301	0.302	0.959	1.000
T-T-A-A-T	0.181	0.145	0.204	0.042	0.175
C-C-C-A-T	0.084	0.084	0.084	0.971	1.000

The haplotype association analysis was performed using the HaploView 4.2 software. The p-value of T-T-A-A-T showed a statistically significant difference, but there was no significant difference after 10⁴ permutation tests

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