No association between polymorphisms in PTEN and primary ovarian insufficiency in a Han Chinese population

Table 1 The allele frequencies of the seven SNPs in PTEN between POI patients and controls

SNP	Alleles	Associated allele	HWE cases	HWE controls	MAF cases (n = 148)	MAF controls (n = 230)	OR	95 % CI	Value	p	Bonferroni correction
rs1234219	T/C	C	0.95	0.72	0.084	0.084	1.010	0.596–1.711	0.001	0.971	1.000
rs1903858	C/T	C	0.60	0.90	0.446	0.509	0.777	0.579–1.043	2.834	0.092	0.644
rs2299939	C/A	C	0.45	0.16	0.146	0.206	0.661	0.445–0.982	4.230	0.040	0.280
rs35352882	T/C	C	0.58	0.51	0.044	0.042	1.047	0.509–2.153	0.015	0.901	1.000
rs17107001	G/T	T	0.64	0.63	0.037	0.031	1.208	0.541–2.697	0.212	0.645	1.000
rs2299941	A/G	G	0.68	0.62	0.378	0.354	1.111	0.820–1.505	0.460	0.498	1.000
rs12572106	T/C	C	0.74	0.44	0.443	0.389	1.245	0.925–1.676	2.091	0.148	1.000

The allele frequencies were performed with Pearson’s chi-squared test or Fisher’s exact test using SPSS 13.0 software. The allele frequencies of rs2299939 showed no significant difference after Bonferroni correction between POI patients and the controls

ISSN: 1477-7827