Progesterone-mediated effects on gene expression and oocyte-cumulus complex transport in the mouse fallopian tube

Table 1 Progesterone receptor antagonists accelerate the transport of the oocyte cumulus complex (OCC) in mouse fallopian tube

	Percent of Mice with OCCs in the Fallopian Tube (number)
	Hours after hCG Treatment
Treatment	24	27	30	36	48
Vehicle	75 (8)	100 (8)	100 (8)	62.5 (8)	0 (8)
Org 31710 (8 μg/g)	100 (8)	62.5 (8)	25 (8)*	0 (8)*	0 (8)
CDB2194 (8 μg/g)	100 (5)	20 (5)*	0 (5)*	0 (5)	0 (5)

Total number of mice in each group is given in parenthesis. Vehicle or antagonist (Org 31710 or CDB2194) were administered 6 h after an injection with human chorionic gonadotropin (hCG). At each sampling point, Fisher’s exact test was used to calculate if the ratio of mice with OCC present in the fallopian tube differed between mice administered vehicle or either antagonist. The time points where the number of mice with OCC is significantly different from the vehicle group are indicated by an asterisk.

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