Table 2 Criteria of methotrexate (MTX) treatment for ectopic pregnancy (EP)

Indications

• Haemodynamically stable patients

• Minimal or no symptoms

• Serum hCG is < 5000 IU/L

• Ectopic mass < 3.5 cm

• No embryonic cardiac activity

• Confirmed diagnosis of ectopic pregnancy

• Able to comply with the follow-up

Contraindications

• Hemodynamically unstable

• Suspected ruptured EP

• Heterotopic pregnancy

• Pregnancy of unknown location

• Breastfeeding

• Chronic liver disease

• Renal disease

• Active peptic ulcer or colitis

• Active pulmonary disease

• Immunodeficiency

• Haematological disease

• Sensitivity to MTX

• Unable to comply with visits and follow-up