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Table 1 Studies regarding the use of aromatase inhibitors for postmenopausal endometriosis

From: Aromatase inhibitors in post-menopausal endometriosis

Study (year) Study type Age Menopause Use of HRT during menopause Clinical manifestation Previous interventions fendometriosis treatment Interventions Treatment in months Outcome Supplementation for osteoporosis Side effects
          Pain Lesion size reduction Other outcomes   
Takayama et al. (1998) [11] Case Report 57 Surgical Yes Polypoid mass at the
vaginal apex (recurrence)
Surgery
Megestrol acetate
Anastrozole 1 mg 9 months Pain relief after 1 month-discontinue of pain medication Size before therapy 30 × 30 × 20
after 6 months 6 × 3 × 5.
Change in mass color from red to pale gray. Alendronate
(1 mg/d) for
9 months, calcium (1.5 g/d) and
vitamin D (800 U/d)
Reduction in bone mineral density (mild) lumbar spine-6.2%, femoral neck-3.7%
Fatemi et al (2005) [7] Case Report 55 Surgical Yes Mass 4 × 8 cm (recurrence) Surgery
GnRH agonist
Letrozole 2.5 mg 18 months Started to reduce after 3 months,
At 12 months completely asymptomatic
Size before therapy 4 × 8
3 months no reduction
6th month 6 × 5
18th month 1 cm
No active capitation of contrast during CT scan (18 months) Alendronate (70 mg/week) Vit D (440/day), calcium (1,2 g/day) No  
Mousa et al (2007) [21] Case Report Middle-aged Unclear No Endometriotic nodule in bladder wall (recurrence) No Exemestane 25 mg 15 days No improvement NA NA No No  
        Letrozole 2.5 mg 4 months Pain relief
Urinary tract symptoms relieved
NA NA No Hot flushes  
        Letrozole 2.5 mg 4 months Pain relief
Urinary tract symptoms relieved
NA NA No No  
Bohrer et al (2008) [22] Case Report 47 Surgical No Ureteral endometriosis
Bowel endometriosis
(recurrence)
Surgery
Megestrol acetate
GnRH agonist
Anastrazole 1 mg 15 months Pain relief
Bowel symptoms resolved
NA NA No NA  
Sasson et al (2009) [23] Case Report 61 Natural No Mass 12.5 × 8 cm (recurrence) Surgery Letrozole 5 m
+MPA 10 mg after the 3rd wk
(repeated aspirations
4 months NA Size before 12.7 × 8.2 × 10.0 cm
2nd week, minimal change
4th month size 6.6 × 8.5 × 4.2 cm
NA No NA