Table 2 Available randomized trials regarding the use of letrozole during the luteal phase in oocyte donors
Luteal phase supplementation | Days of administration | Patients (N) | Serum estradiol levels (mean values) | LH levels (mean values) | |||||
|---|---|---|---|---|---|---|---|---|---|
LUTEAL PHASE | Day 4 | Day 7 | Day 10 | Day 4 | Day 7 | Day 10 | |||
Fatemi 2008 [14] | Letrozole 5 mg | For 14 days from OPU | 3 | 272 | 229 | 31 | 0.2 | 0.1 | 0.1 |
Placebo | 3 | 749 | 1457 | 1308 | 0.2 | 0.1 | 0.1 | ||
Garcia-Velasco 2009 [15] | Letrozole 2.5 mg | For 5 days from OPU | 15 | 279 | 240 | 40 | 0.21 | 0.18 | 0.40 |
Placebo (folic acid) | 15 | 1586 | 855 | 448 | 0.06 | 0.02 | 0.16 | ||