Dehydroepiandrosterone (DHEA) supplementation in diminished ovarian reserve (DOR)

Table 2 Effectiveness of DHEA supplementation in IVF pregnancies based on preconception AMH levels

DHEA effects	Reference
Pregnancies/live births at all AMH levels; Not even undetectable levels of AMH, therefore, preclude pregnancies/live births;	[31]
Pregnancies lowest ^a at AMH levels <0.1 (undetectable) -0.4 ng/mL, intermediate ^b at AMH 0.41-1.05 ng/ML and high ^c ≥ AMH 1.06 ng/mL;	[31]
Spontaneous miscarriage rates lowest ^d at AMH ≤ 0.4 ng/mL and 1.06 ng/mL; Highest ^e at AMH 0.41-1.05 ng/mL;	[31]
Live births rates uniformly low ^f at AMH <0.1-1.05 ng/mL and high ^g at AMH ≥ 1.6 ng/mL;	[31]
AMH increases in parallel with length of DHEA supplementation;	[32]
This increase is more pronounced in younger POA than older DOR patients;	[32]
Improvement in AMH levels with DHEA supplementation is highly predictive of pregnancy success	[32]

^aApproximately 5% per cycle, 10% cumulative; ^b Approximately 10% per cycle and 17% cumulative;
^cApproximately 28% per cycle and 42% cumulative; ^d Approximately <15%; ^e Approximately 50%;
^fApproximately 4% per cycle, 7% cumulative; ^g Approximately 22% per cycle, 32% cumulative;
Date extracted from Gleicher et al [31].

ISSN: 1477-7827