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Table 6 Summary and projected pregnancy rate compensating for the double counting of pregnancies in case a subject has more than one pregnancy

From: Should a single blastocyst transfer policy be a clinical decision or should it depend on the embryological evaluation on day 3?

 

eSET with elective day 5 transfer

eSET with transfer day 3 or 5

Statistical significance

No. of fresh cycles

341

249

 

No. of thawed cycles

188

143

 

Subjects with fresh or thawed clinical pregnancy

147

100

 

Subjects with fresh or thawed ongoing pregnancy

142

91

 

Number of embryos unthawed1

38

98

 

Clinical pregnancy rate thawed embryos

26/286 (9.09)

21/229 (9.17)

NS

Ongoing pregnancy rate thawed embryos

24/286 (8.39)

18/229 (7.86)

NS

Projected number subjects with clinical pregnancy2

3.45

9.68 (1.24+8.44)

 

Projected number subjects with a ongoing pregnancy2

3.19

8.20 (1.24+6.96)

 

Projected cumulative clinical pregnancy rate3

150.45/341 (44.12)

109.68/249 (44.04)

NS

Projected cumulative ongoing pregnancy rate3

145.19/341 (42.58)

99.20/249 (39.84)

NS

  

Day 3

Day 5

 

No. of fresh cycles

 

135

102

 

No. of thawed cycles

 

41

102

 

Subjects with fresh or thawed clinical pregnancy

 

43

57

 

Subjects with fresh or thawed ongoing pregnancy

 

40

51

 

Number of embryos unthawed2

 

26

72

 

Clinical pregnancy rate thawed embryos

 

4/84 (4.76)

17/145 (11.72)

NS

Ongoing pregnancy rate thawed embryos

 

4/84 (4.76)

14/145 (9.66)

NS

Projected number subjects with clinical pregnancy

 

1.24

8.44

 

Projected number subjects with a ongoing pregnancy

 

1.24

6.96

 
  1. 1 Number of embryos unthawed for subjects with no fresh or thawed pregnancy
  2. 2 Projected from the unthawed material among subjects without a fresh or thawed pregnancy, assuming that the pregnancy rate will be the same as for the already thawed material
  3. 3 Fresh pregnancies, thawed pregnancies and projected number of pregnancies/number of subjects