Giant cells. (A) Euryoryzomys in mid gestation (MAV/SJB 01). HE. Trophoblast giant cells (TGC) were accumulated at the outer areas of the placental disk, adjacent to the labyrinth (LAB) and junctional zone (JZ). (B) Euryoryzomys in mid gestation (MAV/SJB 02). TEM. Trophoblast giant cells at higher magnification. These cells were binucleate in nature. (C) Cerradomys, near term (MZUSP/APC 1177-1). HE. A continuous layer of trophoblast giant cells (TGC) was situated between the junctional zone (JZ) and the decidua (D). Some cells were binucleate (arrow). (D) Oligoryzomys, near term (MZUSP 32729-1). HE. Some trophoblast giant cells were multinucleate.