Depletion of the histone chaperone tNASP inhibits proliferation and induces apoptosis in prostate cancer PC-3 cells

Table 1 Cell cycle related genes regulated by the depletion of tNASP

Gene name¹	Gene Symbol (GenBank)²	Fold change
HeLa cells
Cyclin-dependent kinase inhibitor 1A (p21)	CDKN1A (NM_000389)	3.67
Cyclin-dependent kinase 6	CDK6 (NM_001259)	2.69
PC-3 cells
Cyclin D2	CCND2 (NM_001759)	12.45
Cyclin-dependent kinase inhibitor 2A (p16)	CDKN1A (NM_000389)	2.87
Beta-2-microglobulin	B2M (NM_004048)	2.52
Cyclin G2	CCNG2 (NM_004354)	2.46
Cyclin-dependent kinase inhibitor 1A (p21)	CDKN2A (NM_000077)	2.45
Cyclin B2	CCNB2 (NM_004701)	2.4
HUS1checkpoint homolog	HUS1(NM_004507)	-2.15
Cullin2	CUL2 (NM_003591)	-2.6
Cyclin D1	CCND1 (NM_053056)	-9.69
PWR-1E
CDC28protein kinase regulatory subunit 2	CKS2 (NM_001827)	4.38
Cyclin-dependent kinase inhibitor 1A (p21)	CDKN1A(NM_000389)	2.45
Cyclin G2	CCNG2 (NM_004354)	2.42
Cyclin-dependent kinase inhibitor 1B (p27)	CDKN1B (NM_004064)	2.40
Cyclin-dependent kinase 6	CDK6 (NM_001259)	2.25
Cyclin F	CCNF (NM_001761)	2.24
Cyclin D2	CCND2 (NM_001759)	-2.38
B-cell Cell/lymphoma 2	BCL2 (NM_000633)	-2.83

¹ Genes listed present those differentially regulated after HeLa, PC3, RWPE-2, and PWR-1E cells were infected by lentiviral particles containing tNASP shRNA as compared to cells infected with scramble shRNA. The cutoff limit in the analysis was set to two-fold for both induced (+) and repressed (-) genes.
² Gene Bank accession number