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Table 3 Effect of AMA on time course characteristics of levels of βhCG, hPL, and LDH activity in conditioned medium of placental villous CTB in vitro

From: In-vitro effects of the antimicrobial peptide Ala8,13,18-magainin II amide on isolated human first trimester villous trophoblast cells

Test parameter Median value (ranges)
  Time
Treatment 24 h 48 h 96 h
βhCG a
Control 10.5 (9-14) 21.0[*] (13-27) 40.5(*) (26-55)
AMA 8.5 (6-11) 14.0 (9-19) 25.5<*> (11-33)
hPL a
Control 8.5 (7-11) 13.5[*] (7-17) 27.0(*) (13-33)
AMA 9.0 (7-11) 9.5 (6-14) 15.5<*> (11-24)
LDH b    
Control 15.0 (11-20) 18.5 (13-26) 40.5[*] (11-59)
AMA 18.0 (10-23) 22.0 (16-31) 64.5(*) (46-87)
  1. n = 6/each treatment sub-group.
  2. ashown as mIU/ml/105 cells/d. bLDH activity as IU/105 cells/d at 37°C.
  3. (*)P < 0.05 compared with any other group; [*]P < 0.05 compared with other two sub-groups in control treatment group; <*>P < 0.05 compared with other two sub-groups in AMA treatment group.