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Table 3 Effect of AMA on time course characteristics of levels of βhCG, hPL, and LDH activity in conditioned medium of placental villous CTB in vitro

From: In-vitro effects of the antimicrobial peptide Ala8,13,18-magainin II amide on isolated human first trimester villous trophoblast cells

Test parameter

Median value (ranges)

 

Time

Treatment

24 h

48 h

96 h

βhCG a

Control

10.5 (9-14)

21.0[*] (13-27)

40.5(*) (26-55)

AMA

8.5 (6-11)

14.0 (9-19)

25.5<*> (11-33)

hPL a

Control

8.5 (7-11)

13.5[*] (7-17)

27.0(*) (13-33)

AMA

9.0 (7-11)

9.5 (6-14)

15.5<*> (11-24)

LDH b

   

Control

15.0 (11-20)

18.5 (13-26)

40.5[*] (11-59)

AMA

18.0 (10-23)

22.0 (16-31)

64.5(*) (46-87)

  1. n = 6/each treatment sub-group.
  2. ashown as mIU/ml/105 cells/d. bLDH activity as IU/105 cells/d at 37°C.
  3. (*)P < 0.05 compared with any other group; [*]P < 0.05 compared with other two sub-groups in control treatment group; <*>P < 0.05 compared with other two sub-groups in AMA treatment group.
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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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