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Table 1 Classification of TFS groups of genes responding to testosterone and/or MAA

From: Complex modulation of androgen responsive gene expression by methoxyacetic acid

Class Description TFS group TFS Gene Count Response to
     T MAA T/MAA vs. T T/MAA vs. MAA
I No interaction between T and MAA 9.1001 472 Up - - Up
   9.2002 492 Down - - Down
   6.0110 350 - Up Up -
   6.0220 174 - Down Down -
   3.1100 53 Up Up - -
   3.2200 55 Down Down - -
   15.2112 59 Down Up Up Down
IIa MAA enhances action of T 8.0001 421 - - - Up
   8.0002 398 - - - Down
   14.0111 60 - Up Up Up
   14.0222 24 - Down Down Down
IIb T enhances action of MAA 4.0010 355 - - Up -
   4.0020 264 - - Down -
   13.1011 144 Up - Up Up
   13.2022 56 Down - Down Down
IIc T enhances action of MAA, and MAA enhances action of T 15.1111 77 Up Up Up Up
   15.2222 39 Down Down Down Down
   12.0011 316 - - Up Up
   12.0022 81 - - Down Down
IIIa MAA blocks action of T 1.1000 329 Up - - -
   1.2000 307 Down - - -
IIIb T blocks action of MAA 2.0100 302 - Up - -
   2.0200 165 - Down - -
IIIc MAA blocks the action of T, but MAA alone shows no activity 5.1020 62 Up - Down -
   5.2010 52 Down - Up -
IIId T blocks the action of MAA, but T alone shows no activity 10.0102 107 - Up - Down
   10.0201 16 - Down - Up
  1. Regulated genes were clustered based on whether there is an interaction between testosterone and MAA, as follows: Class I represents genes that respond to testosterone or to MAA with no interactive effect. Class II represents genes whose response to testosterone was enhanced by MAA (IIa), genes whose response to MAA was enhanced by testosterone (IIb), and genes whose responses to testosterone and MAA showed mutual enhancement (IIc). Class III corresponds to genes whose response to testosterone could be blocked by MAA (IIIa, IIIc) or whose response to MAA could be blocked by testosterone (IIIb, IIId). See Additional file 2, Table S2C for further details.