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Figure 5 | Reproductive Biology and Endocrinology

Figure 5

From: Complex modulation of androgen responsive gene expression by methoxyacetic acid

Figure 5

GO term enriched in TFS groups. Shown is a hierarchical clustering of GO terms that were significantly enriched (p < 0.0001, and number of included genes >10) in at least one TFS group. GO terms are displayed at the right and TFS group numbers are shown across the top. The color bar at the top left represents -log10 p-values, with higher numbers (darker colors) indicating more significant enrichment. A complete list of enriched GO terms, p-values, enrichment scores and regulated genes in each GO term is provided in Additional file 2, Table S2A. GO terms associated with apoptosis are in the boxed region at the top. TFS groups represent the following groups of genes 9.1001, genes induced by testosterone, both without and with MAA present; 9.2002, genes suppressed by testosterone, both without and with MAA present; 8.0001, genes induced by testosterone, but only in the presence of MAA; 8.0002, genes suppressed by testosterone but only in the presence of MAA; 12.0011, genes induced by testosterone + MAA, relative to testosterone alone and relative to MAA alone; 12.0022, genes suppressed by testosterone + MAA, relative to testosterone and relative to MAA alone; 13.2022, genes suppressed by testosterone either alone or in combination with MAA, and MAA enhances the suppression by testosterone; 1.1000, genes whose induction by testosterone is blocked by MAA; and 10.0102, genes induced by MAA, but only in the absence of testosterone, and suppressed by testosterone, but only in the presence of MAA.

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