Table 5 Functional enrichment analysis (miRGator; [36]) of predicted miRNA targets to uncover selected pathways targeted by miRNAs that are significantly more highly expressed in GD42 (downregulated) and GD75 (upregulated) ovaries and testes.
From: Expression of miRNAs in ovine fetal gonads: potential role in gonadal differentiation
Pathway | XX | XY | ||
|---|---|---|---|---|
| Â | GD42 | GD75 | GD42 | GD75 |
Cell Cycle | 13 | 20 | 15 | 20 |
Chromatin remodelling by hSWI/SNF ATP-dependent complexes | 3 | 1 | 2 | 5 |
Cytokine Network | 6 | 6 | 2 | 3 |
EGF signaling | 4 | 3 | 3 | 2 |
Electron Transport chain | 4 | 3 | 9 | 2 |
G-protein signaling | 8 | 16 | 6 | 15 |
Gap junction proteins connexins | 2 | 1 | 3 | 2 |
Glycolysis and gluconeogenesis | 4 | 3 | 1 | 1 |
Growth hormone signaling | 2 | 2 | 3 | 1 |
Insulin signaling | 3 | 4 | 4 | 2 |
MAPKinase signaling | 10 | 13 | 9 | 12 |
NGF pathway | 3 | 2 | 3 | Â |
PDGF signaling pathway | Â | 4 | 3 | 3 |
Phospholipids as signaling intermediates | Â | 6 | 1 | 4 |
Proteasome degradation | 1 | 7 | 1 | 6 |
Rac 1 cell motility signaling pathway | 1 | 3 | 3 | 2 |
Regulation ER | 5 | 2 | 1 | Â |
TGFbeta signaling pathway | Â | 2 | 1 | 3 |
TNFR Signaling | Â | 3 | Â | 3 |
Transcription factor CREB and its extracellular signals | 1 | 6 | 3 | 4 |
WNT signaling | 5 | 5 | 7 | 8 |