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Table 2 Subgroup analysis of women aged ≤35 years versus > 35 years

From: Ovulation induction with minimal dose of follitropin alfa: a case series study

Characteristic/variable

≤35 years (n = 262)

> 35 years (n = 54)

p value

Age, years

30.7 (2.9)

37.1 (1.1)

0.0001

BMI, kg/m2

23.5 (4.7)

24.6 (3.6)

NS

PCOS, n (%)

182 (69.5)

35 (64.8)

NS

Other/unknown etiology, n (%)

80 (30.5)

19 (35.2)

NS

Duration of infertility, months

27.6 (17.9)

27.8 (21.0)

NS

Number of previous OI cycles

1.9 (1.3)

0.8 (0.8)

0.02

Duration of stimulation, days

11.1 (5.2)

10.6 (4.9)

NS

Total dose of r-hFSH, IU

525 (425)

486 (333)

NS

Cycles cancelled, n (%)

13 (5.0)

1 (1.9)

NS

   Poor response, n (%)

9 (3.4)

1 (1.9)

NS

   OHSS risk, n (%)

4 (1.5)

0 (0)

NS

Number of follicles ≥16 mm in diameter

1.3 (0.6)

1.5 (0.7)

NS

Clinical pregnancy, * n (%)

67 (25.6)

11 (20.4)

NS

   Singleton pregnancy, n (%)

63 (94.0)

11 (100)

NS

   Twin pregnancy, n (%)

4 (6.0)

0 (0)

NS

  1. Values are mean (SD) unless otherwise indicated.
  2. *Defined as gestation ≥7 weeks.
  3. BMI, body mass index; NS, not significant; OHSS, ovarian hyperstimulation syndrome; OI, ovulation induction; PCOS, polycystic ovary syndrome; r-hFSH, recombinant human follicle-stimulating hormone; SD, standard deviation.