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Table 5 Functional annotation clusters for up- and down-regulated transcripts from CERTL obtained through DAVID webtool

From: Bioinformatic detection of E47, E2F1 and SREBP1 transcription factors as potential regulators of genes associated to acquisition of endometrial receptivity

Database

Functional annotation

number of genes

p Value

up-regulated transcripts

GOTERM_CC_FAT

extracellular region

22

<0.0001

SP_PIR_KEYWORDS

signal

22

<0.0001

UP_SEQ_FEATURE

signal peptide

22

<0.0001

GOTERM_BP_FAT

defense response

9

<0.0001

GOTERM_BP_FAT

positive regulation of immune response

7

<0.0001

GOTERM_BP_FAT

inflammatory response

7

<0.0001

GOTERM_BP_FAT

immune effector process

6

<0.0001

GOTERM_BP_FAT

complement activation

5

<0.0001

GOTERM_BP_FAT

immunoglobulin mediated immune response

5

<0.0001

GOTERM_BP_FAT

lymphocyte mediated immunity

5

<0.0001

GOTERM_BP_FAT

activation of immune response

5

<0.0001

KEGG_PATHWAY

Complement and coagulation cascades

5

<0.0001

SP_PIR_KEYWORDS

complement pathway

4

<0.0001

GOTERM_BP_FAT

response to steroid hormone stimulus

4

0.0068

GOTERM_BP_FAT

cell cycle

7

0.0038

down-regulated transcripts

GOTERM_BP_FAT

response to steroid hormone stimulus

4

0.0068

SP_PIR_KEYWORDS

cell cycle

6

0.00045

KEGG_PATHWAY

cell cycle

4

0.0038

GOTERM_BP_FAT

cell division

5

0.0028

GOTERM_BP_FAT

cell cycle

7

0.0038

GOTERM_BP_FAT

regulation of cell cycle

6

0.00047

SP_PIR_KEYWORDS

developmental protein

6

0.0041

UP_SEQ_FEATURE

metal ion-binding site:Zinc 1

3

0.0053

  1. Enriched functional annotations found in GATHER (Table 4) and DAVID (table 5) appear in bolded style.