Bioinformatic detection of E47, E2F1 and SREBP1 transcription factors as potential regulators of genes associated to acquisition of endometrial receptivity

Table 1 Endometrial gene expression reports performed at the time of implantation in human using DNA microarray

Study	First sample (day of cycle, number of samples)	Second sample (day of cycle, number of samples)	Microarrays platform	Fold-change cut-off value	N° of up-regulated transcripts	N° of down-regulated transcripts
Kao et al. (2002) [11]	Proliferative phase (8-11, n = 4)	Mid-secretory (21-23, n = 7)	Affymetrix Hu95A	≥2.0	156	377
Carson et al. (2002) [13]	Early-secretory (15-17, n = 3*)	Mid-secretory (20-22, n = 3*)	Affymetrix Hu95A	≥2.0	323	370
Borthwick et al. (2003) [12]	Proliferative phase (9-11, n = 5*)	Mid-secretory (19-21, n = 5*)	Affymetrix Hu95A-E	≥2.0	90	46
Riesewijk et al. (2003) [14]	Early-secretory (15, n = 5)	Mid-secretory (20, n = 5)	Affymetrix Hu95A	≥3.0	153	58
Mirkin et al. (2005) [15]	Early-secretory (16, n = 3)	Mid-secretory (21, n = 5)	Affymetrix HG_U95Av2	≥2.0	49	58
Talbi et al. (2006)^¶ [9]	Early-secretory (n = 3)	Mid-secretory (n = 8)	Affymetrix HG-U133 plus 2.0	≥1.5	1415	1463
Haouzi et al. (2009)^† [18]	Early-secretory (16, n = 31)	Mid-secretory (20, n = 31)	Affymetrix HG-U133 plus 2.0	≥2.0	945	67

* = pooled samples, ^¶ = day the cycle not specified, ^† = reports only the top 20 up-regulated genes as supplementary data, timing of endometrial biopsies based on first day of menses and not confirmed, possible endometrial pathologies were not excluded

ISSN: 1477-7827