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Table 2 Functional classification of genes the expression of which in TM4 cells was modulated by NP

From: miRNA regulation of cytotoxic effects in mouse Sertoli cells exposed to nonylphenol

Function

No. of genes

 

3 h

24 h

Transport

77

278

Signal transduction

102

250

Transcription

73

169

Cell differentiation

38

119

Cell cycle

28

100

Response to stress

38

78

Lipid metabolism

20

75

Apoptosis

28

70

Cell adhesion

23

70

Behavior

11

59*

Cell proliferation

19

54

Protein biosynthesis

18

54

Immune response

20

42

Angiogenesis

10

29

Homeostasis

7

28

Growth

6

26

Cell-cell signaling

7

19

Gametogenesis

3

17*

Spermatogenesis

1

12*

Inflammatory response

6

10

Total number of genes

535

1,559

  1. *Number of genes hit into the categories remarkably increased (over 5-fold) at 24 h comparing to at 3 h