Authors | Type of study | Controls | Endometriosis | Methodology | Results |
---|---|---|---|---|---|
Abrao et al., 1997 | Case-control study | N = 15 Time 1 Menstrual phase μg/ml: 1.58 ± 0.31 Time 2: Proliferative phase μg/ml: 1.53 ± 0.33 | N = 35 Stage I-II = 20 Stage III-IV = 15 Menstrual phase μg/ml: Stage I-II: 5.06 ± 1.32 Stage III-IV: 13.15 ± 2.55 Proliferative phase μg/ml: Stage I-II: 2.89 ± 0.59 Stage III-IV: 3.52 ± 0.41 | Serum Laparoscopically confirmed or excluded endometriosis Menstrual and Proliferative phases of cycle Home-made ELISA | Difference: Time1-Time 2 Controls: 0.05 ± 0.38 Stage I-II: 2.17 ± 1.16 Stage III-IV: 9.63 ± 2.34 Increased levels of CRP in endometriosis (especially for stages III-IV) |
Lermann et al., 2010 | Prospective nonrandomized controlled trial | N = 34 CRP: 2.88 ± 2.79 ng/ml hsCRP: 2.48 ± 3.77 ng/ml | N = 48 Stage I: 7 Stage II: 5 Stage III: 18 Stage IV: 18 CRP: 3.54 ± 3.24 hsCRP: 3.61 ± 4.82 | Serum Laparoscopically confirmed or excluded endometriosis Early Proliferative cycle phase CRP and hsCRP methods (details Not Available) | NS differences |
Matarese et al., 2000 | Case-control study | N = 15 | N = 13 Stage I-II: 7 Stage III-IV: 6 | Serum Laparoscopically confirmed or excluded endometriosis Proliferative and secretive cycle phase N Latex CRP monokit (Bering Nephelometer Systems) | CRP serum concentrations were less than 3.5 mg/L in all subjects |
Mihalyi et al., 2010 | Case-control study | N = 93 All phases: 0.64 (0.11-15.03) mg/L Secretory phase 0.56 (0.11-14.14) mg/L | N = 201 All phases Stage III-IV: 1.35 (0.23-34.78) mg/L Secretory phase Stage I-IV: 0.88 (0.12-27.23) mg/L | EDTA Plasma Laparoscopically confirmed or excluded endometriosis Menstrual, Proliferative and Secretory phases hsCRP method: HS Tina-quant CRP (latex) hs assay (Roche, Vilvoorde, Belgium) | Significant increase in Stage III-IV (independent of cycle phase and in the luteal phase (p < 0.0001; p = 0.001respectively) Significant increase in Stage I-IV of endometriosis in the luteal phase (p = 0.03) |
Xavier et al., 2005 | Case-control study | N = 13 Early proliferative: 0.68 (0.19-2.22) mg/L Late proliferative: 0.59 (0.21-1.28) mg/L Early secretory: 0.90 (0.42-2.31) mg/L Late secretory: 0.87 (0.22-1.52) mg/L | N = 25 Stage III-IV Early proliferative: 2.29 (0.70-3.54) mg/L Late proliferative: 1.10 (0.30-2.06) mg/L Early secretory: 1.09 (0.39-2.62) mg/L Late secretory: 0.60 (0.28-3.19) mg/L | Serum Early and late Proliferative phase Early and late Secretory phase hsCRP two-site homemade ELISA | NS differences |